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AM6545

CAT: 0013-GTR19201455-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19201455-01Size:1 mg
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Description
AM6545 is a selective, peripherally restricted CB1 antagonist with CB2 inhibitory activity. It has demonstrated efficacy in ameliorating obesity and improving adipokine profiles in monosodium glutamate-induced obese mouse models, making it a valuable research tool for studying metabolic disorders such as obesity and diabetes.
CAS Number
1245626-05-4
Product Name Alternative
AM6545, AM-6545, AM 6545, Cannabinoid Receptor, CannabinoidReceptor, CB1R, CB2R
Field of Research
Pharmacology & Drug Discovery
Purity
97.03% (May vary between batches)
Solubility
DMSO:5 mg/mL (8.99 mM)
Smiles
N#CCCC#CC=1C=CC (=CC1) C2=C (C (=NN2C3=CC=C (Cl) C=C3Cl) C (=O) NN4CCS (=O) (=O) CC4) C
Molecular Formula
C26H23Cl2N5O3S
Molecular Weight
556.46
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

AM6545

AM6545 is a member of the class of pyrazoles that is 1H-pyrazole substituted by 2,4-dichlorophenyl, N-(1,1-dioxidothiomorpholin-4-yl)aminoacyl, methyl, and 4-(4-cyanobut-1-yn-1-yl)phenyl groups at positions 1, 3, 4 and 5, respectively. It is a cannabinoid receptor 1 antagonist and a potential appetite suppressant. It has a role as an appetite depressant, a CB1 receptor antagonist and an anti-obesity agent. It is a nitrile, a dichlorobenzene, a member of pyrazoles, a carbohydrazide, a sulfone, a member of thiomorpholines and an arylacetylene.

CAS Number1245626-05-4
PubChem CID46912919
IUPAC Name5-[4-(4-cyanobut-1-ynyl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxo-1,4-thiazinan-4-yl)-4-methylpyrazole-3-carboxamide
Molecular FormulaC26H23Cl2N5O3S
Molecular Weight556.5
XLogP4.5
Topological Polar Surface Area116
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count37
Formal Charge0
Complexity1020
SMILES
CC1=C(N(N=C1C(=O)NN2CCS(=O)(=O)CC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)C#CCCC#N
InChI
InChI=1S/C26H23Cl2N5O3S/c1-18-24(26(34)31-32-13-15-37(35,36)16-14-32)30-33(23-11-10-21(27)17-22(23)28)25(18)20-8-6-19(7-9-20)5-3-2-4-12-29/h6-11,17H,2,4,13-16H2,1H3,(H,31,34)
InChIKey
XBHQLFVDGLPBCK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of AM6545
CAS: 1245626-05-4
CID: 46912919
Formula: C26H23Cl2N5O3S
MW: 556.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight556.5
XLogP34.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass555.0898662
Monoisotopic Mass555.0898662
Topological Polar Surface Area116 Ų
Heavy Atom Count37
Formal Charge0
Complexity1020
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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