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IWP 12

CAT: 0013-GTR19201218-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19201218-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IWP-12 is a potent and selective small-molecule inhibitor of Porcupine (Porcn), a key enzyme in Wnt ligand secretion. By blocking the Wnt signaling pathway, it is a valuable tool for studying Wnt-dependent processes, including tissue regeneration, as demonstrated by its inhibition of fin regrowth in zebrafish models.
CAS Number
688353-45-9
Product Name Alternative
IWP12, IWP-12, IWP 12
Field of Research
Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.88% (May vary between batches)
Solubility
DMSO:20 mg/mL (47.78 mM)
Smiles
O=C1C=2SC (C) CC2N=C (SCC (=O) NC3=NC=4C=CC (=CC4S3) C) N1C
Molecular Formula
C18H18N4O2S3
Molecular Weight
418.56
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-[(3,6-dimethyl-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide
CAS Number688353-45-9
PubChem CID3244448
IUPAC Name2-[(3,6-dimethyl-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide
Molecular FormulaC18H18N4O2S3
Molecular Weight418.6
XLogP3.7
Topological Polar Surface Area154
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity711
SMILES
CC1CC2=C(S1)C(=O)N(C(=N2)SCC(=O)NC3=NC4=C(S3)C=C(C=C4)C)C
InChI
InChI=1S/C18H18N4O2S3/c1-9-4-5-11-13(6-9)27-17(19-11)21-14(23)8-25-18-20-12-7-10(2)26-15(12)16(24)22(18)3/h4-6,10H,7-8H2,1-3H3,(H,19,21,23)
InChIKey
RBFDSBJDWZOTGR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-[(3,6-dimethyl-4-oxo-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide
CAS: 688353-45-9
CID: 3244448
Formula: C18H18N4O2S3
MW: 418.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight418.6
XLogP33.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass418.05918935
Monoisotopic Mass418.05918935
Topological Polar Surface Area154 Ų
Heavy Atom Count27
Formal Charge0
Complexity711
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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