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McN-A 343

CAT: 0013-GTR19201144-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19201144-02Size:25 mg
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Description
McN-A 343 is a selective M1 muscarinic receptor agonist that enhances ganglionic transmission. It has demonstrated efficacy in preclinical models, reducing inflammation and oxidative stress associated with ulcerative colitis, supporting research in gastroenterology and neuroimmunology.
CAS Number
55-45-8
Product Name Alternative
MAChR M1, McN A 343, McNA 343, McN-A 343, McN-A343, McN-A-343
Field of Research
Neuroscience
Purity
99.65% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.4 mM) ; H2O:< 31.72 mg/mL; DMSO:90 mg/mL (283.72 mM)
Smiles
[Cl-].C[N+] (C) (C) CC#CCOC (=O) Nc1cccc (Cl) c1
Molecular Formula
C14H18Cl2N2O2
Molecular Weight
317.21
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-((((3-Chlorophenyl)amino)carbonyl)oxy)-N,N,N-trimethyl-2-butyn-1-aminium chloride (1:1)

A drug that selectively activates certain subclasses of muscarinic receptors and also activates postganglionic nicotinic receptors. It is commonly used experimentally to distinguish muscarinic receptor subtypes.

CAS Number55-45-8
PubChem CID5926
IUPAC Name4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium chloride
Molecular FormulaC14H18Cl2N2O2
Molecular Weight317.2
Topological Polar Surface Area38.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count20
Formal Charge0
Complexity365
SMILES
C[N+](C)(C)CC#CCOC(=O)NC1=CC(=CC=C1)Cl.[Cl-]
InChI
InChI=1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H
InChIKey
CXFZFEJJLNLOTA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-((((3-Chlorophenyl)amino)carbonyl)oxy)-N,N,N-trimethyl-2-butyn-1-aminium chloride (1:1)
CAS: 55-45-8
CID: 5926
Formula: C14H18Cl2N2O2
MW: 317.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight317.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass316.0745332
Monoisotopic Mass316.0745332
Topological Polar Surface Area38.3 Ų
Heavy Atom Count20
Formal Charge0
Complexity365
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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