ACY-957

CAT: 0013-GTR19206554-08Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19206554-08Size:100 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

ACY-957 (C001) is a potent, orally bioavailable small molecule that selectively inhibits HDAC1 and HDAC2 with IC50 values of 7 nM and 18 nM, respectively, while showing minimal activity against HDAC3 and other class I/II HDACs. This selectivity profile makes it a valuable chemical probe for epigenetic research in oncology and neurology, supporting both in vitro mechanistic studies and in vivo disease model investigations.

CAS Number

1609389-52-7

Product Name Alternative

HDAC3, HDAC1, HDAC Inhibitor C 001, HDAC Inhibitor C001, HDAC Inhibitor C-001, HDAC2, ACY 957, ACY957, ACY-957

Field of Research

Epigenetics & Chromatin, Molecular Biology

Purity

98.24% (May vary between batches)

Solubility

DMSO:50 mg/mL (116.4 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.66 mM)

Smiles

Nc1ccc (cc1NC (=O) c1ccc2nc (ccc2c1) N1CCNCC1) -c1cccs1

Molecular Formula

C24H23N5OS

Molecular Weight

429.54

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

N-[2-Amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-6-quinolinecarboxamide

CAS Number	1609389-52-7
PubChem CID	72374405
IUPAC Name	N-(2-amino-5-thiophen-2-ylphenyl)-2-piperazin-1-ylquinoline-6-carboxamide
Molecular Formula	C24H23N5OS
Molecular Weight	429.5
XLogP	3.5
Topological Polar Surface Area	112
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Heavy Atom Count	31
Formal Charge	0
Complexity	615

SMILES

C1CN(CCN1)C2=NC3=C(C=C2)C=C(C=C3)C(=O)NC4=C(C=CC(=C4)C5=CC=CS5)N

InChI

InChI=1S/C24H23N5OS/c25-19-6-3-17(22-2-1-13-31-22)15-21(19)28-24(30)18-4-7-20-16(14-18)5-8-23(27-20)29-11-9-26-10-12-29/h1-8,13-15,26H,9-12,25H2,(H,28,30)

InChIKey

VURDNNVAYZDGDK-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1609389-52-7

CID: 72374405

Formula: C24H23N5OS

MW: 429.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	429.5
XLogP3	3.5
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	429.16233155
Monoisotopic Mass	429.16233155
Topological Polar Surface Area	112 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	615
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
BA4125-5	ACY-957
A19666-100	ACY-957 100mg
A19666-2	ACY-957 2mg
A19666-10	ACY-957 10mg
A19666-25	ACY-957 25mg
A19666-5	ACY-957 5mg
A19666-50	ACY-957 50mg
A19666-1	ACY-957 1mg
A19666-10mM-D	ACY-957 10mM * 1mL in DMSO
MBS3601619-01	BM-957

ACY-957

Chemical Information

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