Products for Research Use Only
RegisterLogin

AM-8553

CAT: 0013-GTR19201235-02Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19201235-02Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AM-8553 is a potent and selective piperidine-based inhibitor of the MDM2-p53 interaction. It is utilized in cancer research to reactivate p53 function, demonstrating efficacy in both in vitro cell-based assays and in vivo xenograft tumor models.
CAS Number
1352064-70-0
Field of Research
Cell Biology
Smiles
[C@@H] ([C@H] (C) O) (CC) N1[C@@H] ([C@H] (C[C@@] (CC (O) =O) (C) C1=O) C2=CC (Cl) =CC=C2) C3=CC=C (Cl) C=C3
Molecular Formula
C25H29Cl2NO4
Molecular Weight
478.41
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

{(3r,5r,6s)-5-(3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(2s,3s)-2-Hydroxypentan-3-Yl]-3-Methyl-2-Oxopiperidin-3-Yl}acetic Acid
CAS Number1352064-70-0
PubChem CID56965957
IUPAC Name2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxypentan-3-yl]-3-methyl-2-oxopiperidin-3-yl]acetic acid
Molecular FormulaC25H29Cl2NO4
Molecular Weight478.4
XLogP4.9
Topological Polar Surface Area77.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Heavy Atom Count32
Formal Charge0
Complexity668
SMILES
CC[C@@H]([C@H](C)O)N1[C@@H]([C@H](C[C@](C1=O)(C)CC(=O)O)C2=CC(=CC=C2)Cl)C3=CC=C(C=C3)Cl
InChI
InChI=1S/C25H29Cl2NO4/c1-4-21(15(2)29)28-23(16-8-10-18(26)11-9-16)20(17-6-5-7-19(27)12-17)13-25(3,24(28)32)14-22(30)31/h5-12,15,20-21,23,29H,4,13-14H2,1-3H3,(H,30,31)/t15-,20+,21-,23+,25+/m0/s1
InChIKey
YUALYRLIFVPOHL-VPLUBSIMSA-N
Chemical Structure
2D Structure
2D structure of {(3r,5r,6s)-5-(3-Chlorophenyl)-6-(4-Chlorophenyl)-1-[(2s,3s)-2-Hydroxypentan-3-Yl]-3-Methyl-2-Oxopiperidin-3-Yl}acetic Acid
CAS: 1352064-70-0
CID: 56965957
Formula: C25H29Cl2NO4
MW: 478.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight478.4
XLogP34.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count7
Exact Mass477.1473638
Monoisotopic Mass477.1473638
Topological Polar Surface Area77.8 Ų
Heavy Atom Count32
Formal Charge0
Complexity668
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19154330-01AM-404
GTR19344864-01Calcein AM
GTR19337889-01EDTA-AM
GTR19210642-01AM-112
GTR19208528-01AM-0466
GTR19204906-01RT-AM
GTR19199496-01AM-TS23
GTR19198264-01AM-0687
GTR19195672-01AM-2159
GTR19195671-01AM-3102

Alternative Products

CatalogName
MBS5773479AM-8553
TRC-A432180-50MGAM 8553
TL316822SHARP2 (BHLHE40) Human shRNA Plasmid Kit (Locus ID 8553)
BA5219-5.1AM-6538
BA6990-5.1AM-2099
B7392-100AM 1172
B5370-1BCECF-AM
BA5327-5AM-1638
B4758-5.1BAPTA-AM
FI156054-01AM 630

Popular Products