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Stafib-1

CAT: 0013-GTR19199605-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19199605-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Stafib-1 is a potent and selective STAT5β inhibitor that targets its SH2 domain, exhibiting an IC50 of 154 nM and a Ki of 44 nM. This small molecule is a valuable research tool for studying STAT5β-dependent signaling in cancer and hematopoiesis, with utility in both in vitro and in vivo experimental models.
CAS Number
1688703-26-5
Product Name Alternative
Inhibitor, inhibit, K562, STAT5β, STAT5b, Stafib 1, Stafib1, Stafib-1, STAT
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
97.18% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.48 mM) ; DMSO:95 mg/mL (157.7 mM)
Smiles
O (P (=O) (O) O) C1=C (OP (=O) (O) O) C=CC (CNC (COC2=CC3=C (C=C2) C=C (C (NC4=CC=CC=C4) =O) C=C3) =O) =C1
Molecular Formula
C26H24N2O11P2
Molecular Weight
602.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Stafib-1
CAS Number1688703-26-5
PubChem CID122432036
IUPAC Name[4-[[[2-[6-(phenylcarbamoyl)naphthalen-2-yl]oxyacetyl]amino]methyl]-2-phosphonooxyphenyl] dihydrogen phosphate
Molecular FormulaC26H24N2O11P2
Molecular Weight602.4
XLogP1.5
Topological Polar Surface Area201
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count11
Rotatable Bond Count11
Heavy Atom Count41
Formal Charge0
Complexity982
SMILES
C1=CC=C(C=C1)NC(=O)C2=CC3=C(C=C2)C=C(C=C3)OCC(=O)NCC4=CC(=C(C=C4)OP(=O)(O)O)OP(=O)(O)O
InChI
InChI=1S/C26H24N2O11P2/c29-25(27-15-17-6-11-23(38-40(31,32)33)24(12-17)39-41(34,35)36)16-37-22-10-9-18-13-20(8-7-19(18)14-22)26(30)28-21-4-2-1-3-5-21/h1-14H,15-16H2,(H,27,29)(H,28,30)(H2,31,32,33)(H2,34,35,36)
InChIKey
SMUYYYBDKASIKY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Stafib-1
CAS: 1688703-26-5
CID: 122432036
Formula: C26H24N2O11P2
MW: 602.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight602.4
XLogP31.5
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count11
Rotatable Bond Count11
Exact Mass602.08553358
Monoisotopic Mass602.08553358
Topological Polar Surface Area201 Ų
Heavy Atom Count41
Formal Charge0
Complexity982
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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