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AZD8309

CAT: 0013-GTR19199462-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19199462-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD8309 is a potent and orally bioavailable CXCR2 antagonist that modulates neutrophil migration. It has demonstrated efficacy in reducing pancreatic and pulmonary myeloperoxidase (MPO) and decreasing pancreatic protease activity in preclinical models, supporting its use in researching neutrophilic inflammatory diseases.
CAS Number
333742-48-6
Product Name Alternative
AZD 8309, AZD8309, AZD-8309, CXCR2, GlutathionePeroxidase, Glutathione Peroxidase, MPO
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery
Purity
98.35% (May vary between batches)
Solubility
DMSO:65 mg/mL (169.09 mM)
Smiles
N ([C@@H] (CO) C) C1=C2C (=NC (SCC3=C (F) C (F) =CC=C3) =N1) NC (=O) S2
Molecular Formula
C15H14F2N4O2S2
Molecular Weight
384.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Azd-8309

CXCR2 inhibitor

CAS Number333742-48-6
PubChem CID12073810
IUPAC Name5-[(2,3-difluorophenyl)methylsulfanyl]-7-[[(2R)-1-hydroxypropan-2-yl]amino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
Molecular FormulaC15H14F2N4O2S2
Molecular Weight384.4
XLogP2.9
Topological Polar Surface Area138
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count25
Formal Charge0
Complexity479
SMILES
C[C@H](CO)NC1=NC(=NC2=C1SC(=O)N2)SCC3=C(C(=CC=C3)F)F
InChI
InChI=1S/C15H14F2N4O2S2/c1-7(5-22)18-12-11-13(21-15(23)25-11)20-14(19-12)24-6-8-3-2-4-9(16)10(8)17/h2-4,7,22H,5-6H2,1H3,(H2,18,19,20,21,23)/t7-/m1/s1
InChIKey
SRHSMXLXWORYJK-SSDOTTSWSA-N
Chemical Structure
2D Structure
2D structure of Azd-8309
CAS: 333742-48-6
CID: 12073810
Formula: C15H14F2N4O2S2
MW: 384.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight384.4
XLogP32.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass384.05262437
Monoisotopic Mass384.05262437
Topological Polar Surface Area138 Ų
Heavy Atom Count25
Formal Charge0
Complexity479
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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