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Lesopitron

CAT: 0013-GTR19199008-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19199008-02Size:5 mg
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Description
Lesopitron is an anxiolytic small molecule acting as a presynaptic and postsynaptic 5-HT1A receptor agonist. It demonstrates superior efficacy to classical 5-HT1A agonists in rodent and primate anxiety models, effectively counteracts benzodiazepine withdrawal anxiety, and shows a favorable safety profile without potentiating central nervous system depressants like alcohol. This profile makes it a valuable research tool for investigating serotonin pathways in anxiety disorders, utilizing both in vivo behavioral models and in vitro receptor binding assays.
CAS Number
132449-46-8
Product Name Alternative
5HT Receptor, 5HTReceptor, 5-HT1A, Lesopitron
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.92% (May vary between batches)
Solubility
DMSO:3.21 mg/mL (10.01 mM)
Smiles
C (CCCN1C=C (Cl) C=N1) N2CCN (CC2) C=3N=CC=CN3
Molecular Formula
C15H21ClN6
Molecular Weight
320.82
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Lesopitron

Lesopitron is an anxiolytic with pre- and post-synaptic 5-HT1A agonist activity, which is under development by Esteve.

CAS Number132449-46-8
PubChem CID60813
IUPAC Name2-[4-[4-(4-chloropyrazol-1-yl)butyl]piperazin-1-yl]pyrimidine
Molecular FormulaC15H21ClN6
Molecular Weight320.82
XLogP1.8
Topological Polar Surface Area50.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count22
Formal Charge0
Complexity317
SMILES
C1CN(CCN1CCCCN2C=C(C=N2)Cl)C3=NC=CC=N3
InChI
InChI=1S/C15H21ClN6/c16-14-12-19-22(13-14)7-2-1-6-20-8-10-21(11-9-20)15-17-4-3-5-18-15/h3-5,12-13H,1-2,6-11H2
InChIKey
AHCPKWJUALHOPH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Lesopitron
CAS: 132449-46-8
CID: 60813
Formula: C15H21ClN6
MW: 320.82
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight320.82
XLogP31.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass320.1516224
Monoisotopic Mass320.1516224
Topological Polar Surface Area50.1 Ų
Heavy Atom Count22
Formal Charge0
Complexity317
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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A12950-10Lesopitron dihydrochloride 10mg

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