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NC1153

CAT: 0013-GTR19198834-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19198834-01Size:25 mg
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Description
NC1153 is a selective JAK3 inhibitor that blocks IL-2-mediated STAT5a/b activation. This small molecule is a valuable research tool for studying T-cell signaling and has demonstrated efficacy in promoting allograft survival in preclinical transplantation models, offering a strategy to mitigate toxicity.
CAS Number
150661-91-9
Field of Research
Metabolism Research
Smiles
Cl.Cl.CN (C) CC1CCCCCCCCCC (CN (C) C) C1=O
Molecular Formula
C18H38Cl2N2O
Molecular Weight
369.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

NC1153

a Jnk3 inhibitor; no further information available 9/2005

CAS Number150661-91-9
PubChem CID373395
IUPAC Name2,12-bis[(dimethylamino)methyl]cyclododecan-1-one
Molecular FormulaC18H36N2O
Molecular Weight296.5
XLogP4.3
Topological Polar Surface Area23.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count21
Formal Charge0
Complexity263
SMILES
CN(C)CC1CCCCCCCCCC(C1=O)CN(C)C
InChI
InChI=1S/C18H36N2O/c1-19(2)14-16-12-10-8-6-5-7-9-11-13-17(18(16)21)15-20(3)4/h16-17H,5-15H2,1-4H3
InChIKey
HRQRILLGGNNYSD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of NC1153
CAS: 150661-91-9
CID: 373395
Formula: C18H36N2O
MW: 296.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight296.5
XLogP34.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass296.282763776
Monoisotopic Mass296.282763776
Topological Polar Surface Area23.6 Ų
Heavy Atom Count21
Formal Charge0
Complexity263
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
M12100-01NC1153

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