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Poloxin-2

CAT: 0013-GTR19198732-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19198732-01Size:1 mg
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Description
Poloxin-2 is a potent and selective inhibitor targeting the Polo-box domain (PBD) of Polo-like kinase 1 (Plk1) . It demonstrates anti-tumor activity by reducing Plk1 protein levels in HeLa cells and has been utilized in vitro to study mitosis, cell cycle progression, and cancer therapeutics.
CAS Number
321695-37-8
Product Name Alternative
PLK1, Poloxin2, Poloxin-2, Poloxin 2
Field of Research
Cell Biology
Purity
99.59% (May vary between batches)
Solubility
DMSO:12.5 mg/mL (46.42 mM)
Smiles
N (OC (=O) C1=C (C) C=CC=C1) =C2C (C) =CC (=O) C (C) =C2
Molecular Formula
C16H15NO3
Molecular Weight
269.3
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Poloxin-2
CAS Number321695-37-8
PubChem CID44188683
IUPAC Name[(Z)-(2,5-dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)amino] 2-methylbenzoate
Molecular FormulaC16H15NO3
Molecular Weight269.29
XLogP3.2
Topological Polar Surface Area55.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count20
Formal Charge0
Complexity514
SMILES
CC1=CC=CC=C1C(=O)O/N=C\2/C=C(C(=O)C=C2C)C
InChI
InChI=1S/C16H15NO3/c1-10-6-4-5-7-13(10)16(19)20-17-14-8-12(3)15(18)9-11(14)2/h4-9H,1-3H3/b17-14-
InChIKey
KWDBXGNIGYVOBI-VKAVYKQESA-N
Chemical Structure
2D Structure
2D structure of Poloxin-2
CAS: 321695-37-8
CID: 44188683
Formula: C16H15NO3
MW: 269.29
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight269.29
XLogP33.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass269.10519334
Monoisotopic Mass269.10519334
Topological Polar Surface Area55.7 Ų
Heavy Atom Count20
Formal Charge0
Complexity514
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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