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SB220025

CAT: 0013-GTR19196846-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19196846-02Size:5 mg
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Description
SB220025 is a potent, orally bioavailable, and selective p38 MAPK inhibitor that also suppresses p56Lck and PKC activity. It disrupts endothelial growth hormone-induced calcium signaling and angiogenesis, making it a valuable compound for studying inflammatory diseases such as arthritis in both cellular and animal models.
CAS Number
165806-53-1
Product Name Alternative
SB 220025, SB220025, SB-220025
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction
Purity
99.44% (May vary between batches)
Solubility
DMSO:100 mg/mL (295.53 mM)
Smiles
FC1=CC=C (C=C1) C=2N=CN (C2C=3N=C (N=CC3) N) C4CCNCC4
Molecular Formula
C18H19FN6
Molecular Weight
338.38
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

SB-220025

SB220025 is am member of the class of imidazoles carrying piperidin-4-yl, 4-fluophenyl and 2-aminopyrimidin-4-yl substituents at posiitons 1, 4 and 5 respectively. It has a role as an angiogenesis inhibitor, an anti-inflammatory agent and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a member of imidazoles, a member of piperidines, an organofluorine compound and an aminopyrimidine.

CAS Number165806-53-1
PubChem CID5164
IUPAC Name4-[5-(4-fluorophenyl)-3-piperidin-4-ylimidazol-4-yl]pyrimidin-2-amine
Molecular FormulaC18H19FN6
Molecular Weight338.4
XLogP1.4
Topological Polar Surface Area81.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity424
SMILES
C1CNCCC1N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F
InChI
InChI=1S/C18H19FN6/c19-13-3-1-12(2-4-13)16-17(15-7-10-22-18(20)24-15)25(11-23-16)14-5-8-21-9-6-14/h1-4,7,10-11,14,21H,5-6,8-9H2,(H2,20,22,24)
InChIKey
VSPFURGQAYMVAN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of SB-220025
CAS: 165806-53-1
CID: 5164
Formula: C18H19FN6
MW: 338.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight338.4
XLogP31.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass338.16552279
Monoisotopic Mass338.16552279
Topological Polar Surface Area81.7 Ų
Heavy Atom Count25
Formal Charge0
Complexity424
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
T28681-01SB220025

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