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SB225002

CAT: 0013-GTR19173295-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19173295-01Size:5 mg
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Description
SB225002 is a selective small molecule antagonist of the CXCR2 chemokine receptor, effectively blocking IL-8 binding. It is widely used in research to investigate CXCR2's role in neutrophil migration, inflammation, and cancer biology in both cellular and animal models.
CAS Number
182498-32-4
Product Name Alternative
Inhibit, Inhibitor, CXCR2, CXCR, CXC chemokine receptors, SB 225002, SB225002, SB-225002
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
96.86% (May vary between batches)
Solubility
DMSO:71.4 mg/mL (202.76 mM) ; Ethanol:3 mg/mL (8.52 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.68 mM)
Smiles
N (C (NC1=C (Br) C=CC=C1) =O) C2=C (O) C=C (N (=O) =O) C=C2
Molecular Formula
C13H10BrN3O4
Molecular Weight
352.14
References & Citations
Yan-Hua Zhao, Juan Chen, Tao Gong, Hai-Yan Ge, Min Li Icariin inhibits tumor-associated neutrophil recruitment via the CXCL8-CXCR2 axis and restrains pro-metastatic programs in colorectal cancer WJG, 32 (11), 113325 (2026)
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Sb 225002

SB225002 is a member of the class of phenylureas that is urea in which one of the amino groups is substituted by a (2-bromophenyl)amino group while the other is substituted by a (2-hydroxy-4-nitrophenyl)amino group. It is a potent CXCR2 chemokine receptor antagonist (IC50 = 22 nM). It has a role as an antinociceptive agent, a CXCR2 antagonist, an antineoplastic agent, an anti-inflammatory agent and an apoptosis inducer. It is a member of phenylureas, a nitrophenol and a member of bromobenzenes.

CAS Number182498-32-4
PubChem CID3854666
IUPAC Name1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
Molecular FormulaC13H10BrN3O4
Molecular Weight352.14
XLogP2.6
Topological Polar Surface Area107
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity390
SMILES
C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br
InChI
InChI=1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
InChIKey
MQBZVUNNWUIPMK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Sb 225002
CAS: 182498-32-4
CID: 3854666
Formula: C13H10BrN3O4
MW: 352.14
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight352.14
XLogP32.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass350.98547
Monoisotopic Mass350.98547
Topological Polar Surface Area107 Ų
Heavy Atom Count21
Formal Charge0
Complexity390
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19196846-01SB220025

Alternative Products

CatalogName
T1955-01SB225002
A14209-500SB225002 500mg
A14209-100SB225002 100mg
A14209-25SB225002 25mg
A14209-200SB225002 200mg
A14209-50SB225002 50mg
A14209-10SB225002 10mg
A14209-5SB225002 5mg
A14209-10mM-DSB225002 10mM * 1mL in DMSO

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