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T521

CAT: 0013-GTR19196382-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19196382-01Size:1 mg
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Description
T521 is a potent and selective small-molecule inhibitor targeting the Polo-box domain (PBD) of Plk1, exhibiting high specificity over Plk2 and Plk3. It is a valuable research tool for studying mitotic progression and has been utilized in both in vitro and in vivo cancer research models to investigate Plk1-dependent pathways.
CAS Number
891020-54-5
Product Name Alternative
T 521, T521, T-521, PLK1
Field of Research
Cell Biology, Protein Biochemistry
Purity
99.65% (May vary between batches)
Solubility
DMSO:45 mg/mL (113.8 mM)
Smiles
S (=O) (=O) (C1=C (S (CC) (=O) =O) OC (=N1) C2=CC=C (F) C=C2) C3=CC=CC=C3
Molecular Formula
C17H14FNO5S2
Molecular Weight
395.43
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

5-(Ethylsulfonyl)-2-(4-fluorophenyl)-4-(phenylsulfonyl)-1,3-oxazole
CAS Number891020-54-5
PubChem CID16013351
IUPAC Name4-(benzenesulfonyl)-5-ethylsulfonyl-2-(4-fluorophenyl)-1,3-oxazole
Molecular FormulaC17H14FNO5S2
Molecular Weight395.4
XLogP3.2
Topological Polar Surface Area111
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count26
Formal Charge0
Complexity671
SMILES
CCS(=O)(=O)C1=C(N=C(O1)C2=CC=C(C=C2)F)S(=O)(=O)C3=CC=CC=C3
InChI
InChI=1S/C17H14FNO5S2/c1-2-25(20,21)17-16(26(22,23)14-6-4-3-5-7-14)19-15(24-17)12-8-10-13(18)11-9-12/h3-11H,2H2,1H3
InChIKey
MVTLATINKNLPEJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-(Ethylsulfonyl)-2-(4-fluorophenyl)-4-(phenylsulfonyl)-1,3-oxazole
CAS: 891020-54-5
CID: 16013351
Formula: C17H14FNO5S2
MW: 395.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight395.4
XLogP33.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass395.02974306
Monoisotopic Mass395.02974306
Topological Polar Surface Area111 Ų
Heavy Atom Count26
Formal Charge0
Complexity671
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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