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3,4-Dephostatin

CAT: 0804-HY-124152Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124152Size:1 Each
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Description
3,4-Dephostatin (Methyl-3,4-dephostatin) is an inhibitor of protein-tyrosine phosphatase (PTPase) . 3,4-Dephostatin accelerates nerve growth factor (NGF) -induced neurite formation in PC12h cells. 3,4-Dephostatin sustains the NGF-induced tyrosine phosphorylation of proteins, most prominently that of mitogen-activated protein (MAP) kinase. 3,4-Dephostatin also prolongs epidermal growth factor (EGF) -induced tyrosine phosphorylation and activation of MAP kinase[1].
CAS Number
173043-84-0
Product Name Alternative
Methyl-3,4-dephostatin
UNSPSC
12352005
Target
MAP3K; MAP4K; Phosphatase
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/3-4-dephostatin.html
Smiles
OC1=CC=C(N(C)N=O)C=C1O
Molecular Formula
C7H8N2O3
Molecular Weight
168.15
References & Citations
[1]Fujiwara S, et al. Enhancement or induction of neurite formation by a protein tyrosine phosphatase inhibitor, 3,4-dephostatin, in growth factor-treated PC12h cells. Biochem Biophys Res Commun. 1997 Sep 8;238 (1) :213-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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