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L6Y

CAT: 0013-GTR19194020-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19194020-03Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L6Y is a small molecule stabilizer of transthyretin (TTR) that acts by occupying the thyroxine (T4) binding site, thereby inhibiting tetramer dissociation into amyloidogenic monomers. This mechanism supports its application in researching TTR amyloidosis, including in vitro stabilization assays and in vivo model studies.
CAS Number
881290-53-5
Smiles
C (=O) (C=1C2=C3C (=CC1) C (=O) N (O) C (=O) C3=CC=C2) C4=CC=CC=C4
Molecular Formula
C19H11NO4
Molecular Weight
317.29
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

6-benzoyl-2-hydroxy-1H-benzo(de)isoquinoline-1,3(2H)-dione

stabilzes transthyretin to prevent amyloid formation; structure in first source

CAS Number881290-53-5
PubChem CID7573771
IUPAC Name6-benzoyl-2-hydroxybenzo[de]isoquinoline-1,3-dione
Molecular FormulaC19H11NO4
Molecular Weight317.3
XLogP3
Topological Polar Surface Area74.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count24
Formal Charge0
Complexity554
SMILES
C1=CC=C(C=C1)C(=O)C2=C3C=CC=C4C3=C(C=C2)C(=O)N(C4=O)O
InChI
InChI=1S/C19H11NO4/c21-17(11-5-2-1-3-6-11)13-9-10-15-16-12(13)7-4-8-14(16)18(22)20(24)19(15)23/h1-10,24H
InChIKey
AFGMHSZWGJYWFH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-benzoyl-2-hydroxy-1H-benzo(de)isoquinoline-1,3(2H)-dione
CAS: 881290-53-5
CID: 7573771
Formula: C19H11NO4
MW: 317.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight317.3
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass317.06880783
Monoisotopic Mass317.06880783
Topological Polar Surface Area74.7 Ų
Heavy Atom Count24
Formal Charge0
Complexity554
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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