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MI-389

CAT: 0013-GTR19194434-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19194434-02Size:5 mg
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Description
MI-389 is a PROTAC molecule designed to degrade receptor tyrosine kinases (RTKs) . It serves as a valuable chemical tool for leukemia research, enabling the study of RTK dependency in both cellular and animal models of hematological malignancies.
CAS Number
2222635-92-7
Product Name Alternative
MI 389, MI389, MI-389
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
98.12% (May vary between batches)
Solubility
DMSO:50 mg/mL (76.37 mM)
Smiles
O=C1C=2C (C (=O) N1C3C (=O) NC (=O) CC3) =CC=CC2NCCCCCCNC (=O) C=4C (C) =C (/C=C\5/C=6C (NC5=O) =CC=C (F) C6) NC4C
Molecular Formula
C35H35FN6O6
Molecular Weight
654.69
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 134544040
CAS Number2222635-92-7
PubChem CID134544040
IUPAC NameN-[6-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]hexyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
Molecular FormulaC35H35FN6O6
Molecular Weight654.7
XLogP3.7
Topological Polar Surface Area170
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count8
Rotatable Bond Count11
Heavy Atom Count48
Formal Charge0
Complexity1340
SMILES
CC1=C(NC(=C1C(=O)NCCCCCCNC2=CC=CC3=C2C(=O)N(C3=O)C4CCC(=O)NC4=O)C)/C=C\5/C6=C(C=CC(=C6)F)NC5=O
InChI
InChI=1S/C35H35FN6O6/c1-18-26(17-23-22-16-20(36)10-11-24(22)40-31(23)44)39-19(2)29(18)33(46)38-15-6-4-3-5-14-37-25-9-7-8-21-30(25)35(48)42(34(21)47)27-12-13-28(43)41-32(27)45/h7-11,16-17,27,37,39H,3-6,12-15H2,1-2H3,(H,38,46)(H,40,44)(H,41,43,45)/b23-17-
InChIKey
VXBLUAKQWQJPAD-QJOMJCCJSA-N
Chemical Structure
2D Structure
2D structure of CID 134544040
CAS: 2222635-92-7
CID: 134544040
Formula: C35H35FN6O6
MW: 654.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight654.7
XLogP33.7
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count8
Rotatable Bond Count11
Exact Mass654.26021102
Monoisotopic Mass654.26021102
Topological Polar Surface Area170 Ų
Heavy Atom Count48
Formal Charge0
Complexity1340
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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HY-136688-01MI-389
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