Balapiravir

CAT: 0804-HY-10443-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-10443-01Size:5 mg

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Description

Balapiravir (Ro 4588161; R1626) is an orally active proagent of a nucleoside analogue inhibitor of the RNA-dependent RNA polymerase (RdRp) of HCV (R1479; 4'-Azidocytidine) . Balapiravir has anti-HCV activity[1][2][3]. Balapiravir is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

CAS Number

690270-29-2

Product Name Alternative

Ro 4588161; R1626

UNSPSC

12352005

Target

DNA/RNA Synthesis; HCV

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Balapiravir.html

Purity

97.22

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1N=C(N)C=CN1[C@@H]2O[C@](N=[N+]=[N-])(COC(C(C)C)=O)[C@@H](OC(C(C)C)=O)[C@H]2OC(C(C)C)=O

Molecular Formula

C21H30N6O8

Molecular Weight

494.50

References & Citations

[1]Nguyen NM, et al. A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients. J Infect Dis. 2013 May 1;207 (9) :1442-1450.|[2]Nelson DR, et al. Balapiravir plus peginterferon alfa-2a (40KD) /ribavirin in a randomized trial of hepatitis C genotype 1 patients.Ann Hepatol. 2012 Jan-Feb;11 (1) :15-31.|[3]Yen-Liang Chen, et al. Activation of Peripheral Blood Mononuclear Cells by Dengue Virus Infection Depotentiates Balapiravir. J Virol. 2014 Feb;88 (3) :1740-7.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Alternative Products

Catalog	Name
319850	Balapiravir
QCB27065-01	Balapiravir hydrochloride
MBS386710-01	Balapiravir (R1626)
A11335-50	Balapiravir 50mg
A11335-5	Balapiravir 5mg
A11335-25	Balapiravir 25mg
A11335-10	Balapiravir 10mg
A11335-2	Balapiravir (R1626) 2mg
MBS130555-01	Balapiravir (R1626, Ro 4588161)

Balapiravir

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