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2-Thiouridine

CAT: 0013-GTR19191964-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19191964-01Size:25 mg
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Description
2-Thiouridine (s2U) is a thio-modified nucleoside that enhances the stability of U:A base pairs in RNA while reducing U:G wobble pair fidelity. This property makes it a valuable tool for investigating RNA structure-function relationships and for the design of engineered ribonucleic acids in both in vitro and cellular studies.
CAS Number
20235-78-3
Field of Research
Cell Biology, Molecular Biology
Solubility
DMSO: 40 mg/mL (153.69 mM), H2O: 8 mg/mL (30.74 mM), Ethanol: 2 mg/mL (7.68 mM), PBS (pH 7.2) : 5 mg/mL (19.21 mM), DMF: 10 mg/mL (38.42 mM) . Sonication is recommended.
Smiles
O[C@H]1[C@@H] (O[C@H] (CO) [C@H]1O) N2C (=S) NC (=O) C=C2
Molecular Formula
C9H12N2O5S
Molecular Weight
260.27
Storage Conditions
Powder: -20°C for 3 years. In solvent: -80°C for 1 year.
Notes
For research use only.

Chemical Information

2-Thiouridine

2-thiouridine is a thiouridine in which the oxygen replaced by sulfur is that at C-2. It is a thiouridine and a nucleoside analogue.

CAS Number20235-78-3
PubChem CID3036443
IUPAC Name1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-sulfanylidenepyrimidin-4-one
Molecular FormulaC9H12N2O5S
Molecular Weight260.27
XLogP-1.4
Topological Polar Surface Area134
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Heavy Atom Count17
Formal Charge0
Complexity374
SMILES
C1=CN(C(=S)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
InChI
InChI=1S/C9H12N2O5S/c12-3-4-6(14)7(15)8(16-4)11-2-1-5(13)10-9(11)17/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,17)/t4-,6-,7-,8-/m1/s1
InChIKey
GJTBSTBJLVYKAU-XVFCMESISA-N
Chemical Structure
2D Structure
2D structure of 2-Thiouridine
CAS: 20235-78-3
CID: 3036443
Formula: C9H12N2O5S
MW: 260.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight260.27
XLogP3-1.4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass260.04669266
Monoisotopic Mass260.04669266
Topological Polar Surface Area134 Ų
Heavy Atom Count17
Formal Charge0
Complexity374
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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