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DTAGV-1

CAT: 0013-GTR19191591Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19191591Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This small molecule degrader selectively targets proteins fused to the mutant FKBP12F36V, inducing their degradation via the VHL E3 ligase pathway. It has demonstrated utility in vitro and in vivo, for example in degrading oncogenic FKBP12F36V-EWS/FLI fusions to inhibit proliferation in Ewing sarcoma models. The system enables targeted protein knockdown for functional studies in various research fields.
CAS Number
2451573-86-5
Smiles
CC[C@@H] (C1=CC (OC) =C (C (OC) =C1) OC) C (N2CCCC[C@H]2C (O[C@H] (CCC3=CC (OC) =C (C=C3) OC) C4=CC=CC=C4OCC (NCCCCCCC (N[C@H] (C (N5C[C@@H] (C[C@H]5C (N[C@@H] (C) C6=CC=C (C=C6) C7=C (N=CS7) C) =O) O) =O) C (C) (C) C) =O) =O) =O) =O
Molecular Formula
C68H90N6O14S
Molecular Weight
1247.54
Storage Conditions
-20°C
Notes
For research use only.

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