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PW0464

CAT: 0013-GTR19191005-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19191005-02Size:5 mg
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Description
PW0464 ((Rac) -Razpipadon) is a potent, non-catechol, and G protein-biased dopamine D1 receptor agonist (Gs-cAMP EC50 = 5.8 nM) . It serves as a valuable research tool for investigating D1R signaling in neurological disorders, with applications in both in vitro signaling studies and in vivo models of Parkinson's disease and cognitive dysfunction.
CAS Number
1643462-93-4
Product Name Alternative
(Rac) -Razpipadon, PW 0464, PW0464, PW-0464
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.78% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:1.5 mg/mL (3.85 mM) ; DMSO:18 mg/mL (46.23 mM)
Smiles
O=C1NC (=O) N (C (C=2C=CC (OC3=NC=CC=C3OC (F) F) =CC2C) =C1C) C
Molecular Formula
C19H17F2N3O4
Molecular Weight
389.35
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Razpipadon

Razpipadon is a small molecule drug. Razpipadon is under investigation in clinical trial NCT04958031 (A Trial of the Safety, Tolerability, and Pharmacodynamics of CVL-871 in Subjects With Dementia-Related Apathy). Razpipadon has a monoisotopic molecular weight of 389.12 Da.

CAS Number1643462-93-4
PubChem CID86764103
IUPAC Name6-[4-[[3-(difluoromethoxy)-2-pyridinyl]oxy]-2-methylphenyl]-1,5-dimethylpyrimidine-2,4-dione
Molecular FormulaC19H17F2N3O4
Molecular Weight389.4
XLogP3.3
Topological Polar Surface Area80.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count28
Formal Charge0
Complexity643
SMILES
CC1=C(C=CC(=C1)OC2=C(C=CC=N2)OC(F)F)C3=C(C(=O)NC(=O)N3C)C
InChI
InChI=1S/C19H17F2N3O4/c1-10-9-12(27-17-14(28-18(20)21)5-4-8-22-17)6-7-13(10)15-11(2)16(25)23-19(26)24(15)3/h4-9,18H,1-3H3,(H,23,25,26)
InChIKey
ZXIPVZWZRQCIRW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Razpipadon
CAS: 1643462-93-4
CID: 86764103
Formula: C19H17F2N3O4
MW: 389.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight389.4
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass389.11871236
Monoisotopic Mass389.11871236
Topological Polar Surface Area80.8 Ų
Heavy Atom Count28
Formal Charge0
Complexity643
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T36946-01PW0464

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