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(Z) -4EGI-1

CAT: 0013-GTR19190886-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19190886-01Size:2 mg
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Description
(Z) -4EGI-1 is a cell-permeable inhibitor that disrupts the eIF4E/eIF4G interaction, thereby suppressing cap-dependent translation initiation with an IC50 of 43.5 μM. This compound exhibits anticancer properties and is used in research to study oncogenesis and protein synthesis inhibition in both cellular and animal models.
CAS Number
901787-88-0
Field of Research
Cell Biology
Smiles
N (/N=C (/CC1=C (N (=O) =O) C=CC=C1) \C (O) =O) C2=NC (=CS2) C3=CC (Cl) =C (Cl) C=C3
Molecular Formula
C18H12Cl2N4O4S
Molecular Weight
451.28
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

H57Reu3dhp
CAS Number901787-88-0
PubChem CID6911989
IUPAC Name(2Z)-2-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]-3-(2-nitrophenyl)propanoic acid
Molecular FormulaC18H12Cl2N4O4S
Molecular Weight451.3
XLogP6.1
Topological Polar Surface Area149
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count29
Formal Charge0
Complexity635
SMILES
C1=CC=C(C(=C1)C/C(=N/NC2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl)/C(=O)O)[N+](=O)[O-]
InChI
InChI=1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14-
InChIKey
KFRKRECSIYXARE-HMAPJEAMSA-N
Chemical Structure
2D Structure
2D structure of H57Reu3dhp
CAS: 901787-88-0
CID: 6911989
Formula: C18H12Cl2N4O4S
MW: 451.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight451.3
XLogP36.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass449.9956314
Monoisotopic Mass449.9956314
Topological Polar Surface Area149 Ų
Heavy Atom Count29
Formal Charge0
Complexity635
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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