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UZH1a

CAT: 0013-GTR19190614Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19190614Size:5 mg
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Description
UZH1a is a potent and selective chemical probe targeting METTL3 with an IC50 of 280 nM. It is used to study epitranscriptomics and has demonstrated antitumor activity in cellular and in vivo models, making it a valuable tool for oncology and molecular biology research.
CAS Number
2813577-78-3
Field of Research
Cell Biology
Smiles
C (NC (=O) C1=C (O) C=C (CN2CCC (C) (C) CC2) C=C1) [C@@]3 (O) CN (CCC3) C=4C=C (NCC5=CC=CC=C5) N=CN4
Molecular Formula
C32H42N6O3
Molecular Weight
558.71
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-oxidanyl-~{N}-[[(3~{R})-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide
CAS Number2813577-78-3
PubChem CID154815692
IUPAC NameN-[[(3R)-1-[6-(benzylamino)pyrimidin-4-yl]-3-hydroxypiperidin-3-yl]methyl]-4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-hydroxybenzamide
Molecular FormulaC32H42N6O3
Molecular Weight558.7
XLogP4.8
Topological Polar Surface Area114
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Heavy Atom Count41
Formal Charge0
Complexity828
SMILES
CC1(CCN(CC1)CC2=CC(=C(C=C2)C(=O)NC[C@@]3(CCCN(C3)C4=NC=NC(=C4)NCC5=CC=CC=C5)O)O)C
InChI
InChI=1S/C32H42N6O3/c1-31(2)12-15-37(16-13-31)20-25-9-10-26(27(39)17-25)30(40)34-21-32(41)11-6-14-38(22-32)29-18-28(35-23-36-29)33-19-24-7-4-3-5-8-24/h3-5,7-10,17-18,23,39,41H,6,11-16,19-22H2,1-2H3,(H,34,40)(H,33,35,36)/t32-/m1/s1
InChIKey
PWYRDVXYAOGDNK-JGCGQSQUSA-N
Chemical Structure
2D Structure
2D structure of 4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-oxidanyl-~{N}-[[(3~{R})-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide
CAS: 2813577-78-3
CID: 154815692
Formula: C32H42N6O3
MW: 558.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight558.7
XLogP34.8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Exact Mass558.33183922
Monoisotopic Mass558.33183922
Topological Polar Surface Area114 Ų
Heavy Atom Count41
Formal Charge0
Complexity828
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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