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NP-313

CAT: 0013-GTR19199873-04Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19199873-04Size:25 mg
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Description
NP-313 (NSC-4264) is a small molecule antithrombotic agent that functions by blocking thromboxane A2 synthesis and selectively inhibiting store-operated calcium channel (SOCC) -mediated calcium efflux, thereby preventing platelet aggregation. Its mechanism supports research in cardiovascular diseases, thrombosis models, and platelet function studies in both in vitro and in vivo experimental systems.
CAS Number
5397-78-4
Product Name Alternative
NSC4264, NSC-4264, NSC 4264, NP 313, NP313, NP-313, Calcium Channel, CalciumChannel, Thromboxane A2 synthetase
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry
Purity
98.97% (May vary between batches)
Solubility
DMSO:60 mg/mL (240.34 mM)
Smiles
O=C1C=2C (C (=O) C (Cl) =C1NC (C) =O) =CC=CC2
Molecular Formula
C12H8ClNO3
Molecular Weight
249.65
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-Acetylamino-3-chloro-1,4-naphthoquinone

NP-313 is a specific small molecule inhibitor of ubiquitin-like protein UHRF1, binds with the SRA domain groove of UHRF1.

CAS Number5397-78-4
PubChem CID72754
IUPAC NameN-(3-chloro-1,4-dioxonaphthalen-2-yl)acetamide
Molecular FormulaC12H8ClNO3
Molecular Weight249.65
XLogP0.8
Topological Polar Surface Area63.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count17
Formal Charge0
Complexity427
SMILES
CC(=O)NC1=C(C(=O)C2=CC=CC=C2C1=O)Cl
InChI
InChI=1S/C12H8ClNO3/c1-6(15)14-10-9(13)11(16)7-4-2-3-5-8(7)12(10)17/h2-5H,1H3,(H,14,15)
InChIKey
OMXMYDUYAUOFRX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Acetylamino-3-chloro-1,4-naphthoquinone
CAS: 5397-78-4
CID: 72754
Formula: C12H8ClNO3
MW: 249.65
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight249.65
XLogP30.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass249.0192708
Monoisotopic Mass249.0192708
Topological Polar Surface Area63.2 Ų
Heavy Atom Count17
Formal Charge0
Complexity427
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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