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Cgp 43182

CAT: 0013-GTR19195147-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19195147-02Size:50 mg
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Description
CGP 43182 is a potent and selective inhibitor of Group IIA sPLA2 enzyme activity. It is utilized in research to investigate inflammatory pathways, as it blocks the NF-κB-mediated synergistic upregulation of pro-inflammatory genes induced by cytokines in vitro. This compound serves as a key tool for studying sPLA2's role in models of inflammation.
CAS Number
150379-37-6
Smiles
O=C1OC2 (OC (O) =C1C (NC3=C (Cl) C (Cl) =CC=C3) =O) CCCCC2
Molecular Formula
C16H15Cl2NO5
Molecular Weight
372.2
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Cgp 43182
CAS Number150379-37-6
PubChem CID127704
IUPAC NameN-(2,3-dichlorophenyl)-2-hydroxy-4-oxo-1,5-dioxaspiro[5.5]undec-2-ene-3-carboxamide
Molecular FormulaC16H15Cl2NO5
Molecular Weight372.2
XLogP4.5
Topological Polar Surface Area84.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count24
Formal Charge0
Complexity559
SMILES
C1CCC2(CC1)OC(=C(C(=O)O2)C(=O)NC3=C(C(=CC=C3)Cl)Cl)O
InChI
InChI=1S/C16H15Cl2NO5/c17-9-5-4-6-10(12(9)18)19-13(20)11-14(21)23-16(24-15(11)22)7-2-1-3-8-16/h4-6,21H,1-3,7-8H2,(H,19,20)
InChIKey
KSXVYLXVMKLSOE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cgp 43182
CAS: 150379-37-6
CID: 127704
Formula: C16H15Cl2NO5
MW: 372.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight372.2
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass371.0327280
Monoisotopic Mass371.0327280
Topological Polar Surface Area84.9 Ų
Heavy Atom Count24
Formal Charge0
Complexity559
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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