IL-4-inhibitor-1

CAT: 0013-GTR19191343-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19191343-01Size:1 mg

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Description

This small molecule IL-4 inhibitor selectively binds IL-4 (Kd = 1.8 μM) to block the IL-4/JAK1/STAT6 signaling pathway, as demonstrated by its inhibition of IL-4-induced STAT6 phosphorylation in THP-1 cells. It is a valuable research tool for studying type 2 immune responses in asthma and allergy models, both in vitro and in vivo.

CAS Number

1332184-63-0

Product Name Alternative

IL4inhibitor1, IL-4-inhibitor-1, IL-4, ILReceptor, IL Receptor, IL 4 inhibitor 1

Field of Research

Immunology & Inflammation, Immunology & Inflammation; Pharmacology & Drug Discovery

Purity

98.26% (May vary between batches)

Solubility

Ethanol:10 mg/mL (31.12 mM) ; DMF:27 mg/mL (84.03 mM) ; DMSO:PBS (pH 7.2) (1:5) :0.1 mg/mL (0.31 mM) ; DMSO:50 mg/mL (155.61 mM)

Smiles

Nc1nc (cc (-c2ccc (O) c (O) c2) c1C#N) -c1ccc (F) cc1

Molecular Formula

C18H12FN3O2

Molecular Weight

321.31

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

IL-4-inhibitor-1

CAS Number	1332184-63-0
PubChem CID	136164931
IUPAC Name	2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)pyridine-3-carbonitrile
Molecular Formula	C18H12FN3O2
Molecular Weight	321.3
XLogP	3.5
Topological Polar Surface Area	103
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Heavy Atom Count	24
Formal Charge	0
Complexity	474

SMILES

C1=CC(=CC=C1C2=NC(=C(C(=C2)C3=CC(=C(C=C3)O)O)C#N)N)F

InChI

InChI=1S/C18H12FN3O2/c19-12-4-1-10(2-5-12)15-8-13(14(9-20)18(21)22-15)11-3-6-16(23)17(24)7-11/h1-8,23-24H,(H2,21,22)

InChIKey

DWZPPBGRCDPFSS-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1332184-63-0

CID: 136164931

Formula: C18H12FN3O2

MW: 321.3

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	321.3
XLogP3	3.5
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	321.09135480
Monoisotopic Mass	321.09135480
Topological Polar Surface Area	103 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	474
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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BA6014-10	IL-4-inhibitor-1
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IL-4-inhibitor-1

Chemical Information

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