SX-517

CAT: 0013-GTR19196392-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19196392-01Size:5 mg

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Description

SX-517 is a potent non-competitive dual antagonist of CXCR1/2 receptors. It exhibits anti-inflammatory activity by inhibiting CXCL-1-induced calcium mobilization and CXCL-8-mediated GTPγS binding, while also suppressing ERK1/2 phosphorylation in cellular assays and mouse models.

CAS Number

1240494-13-6

Product Name Alternative

SX 517, SX517, SX-517

Field of Research

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Purity

99.90% (May vary between batches)

Solubility

DMSO:80 mg/mL (209.3 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (8.63 mM)

Smiles

O=C (NC1=CC=C (F) C=C1) C2=CN=C (SCC=3C=CC=CC3B (O) O) C=C2

Molecular Formula

C19H16BFN2O3S

Molecular Weight

382.22

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

SX-517

CAS Number	1240494-13-6
PubChem CID	46897162
IUPAC Name	[2-[[5-[(4-fluorophenyl)carbamoyl]-2-pyridinyl]sulfanylmethyl]phenyl]boronic acid
Molecular Formula	C19H16BFN2O3S
Molecular Weight	382.2
Topological Polar Surface Area	108
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Heavy Atom Count	27
Formal Charge	0
Complexity	480

SMILES

B(C1=CC=CC=C1CSC2=NC=C(C=C2)C(=O)NC3=CC=C(C=C3)F)(O)O

InChI

InChI=1S/C19H16BFN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24)

InChIKey

VZRIHFZJVIOJBE-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1240494-13-6

CID: 46897162

Formula: C19H16BFN2O3S

MW: 382.2

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	382.2
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	382.0958719
Monoisotopic Mass	382.0958719
Topological Polar Surface Area	108 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	480
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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GTR19165913-01	SX-682
GTR19160226-01	BX-517
GTR19171903-01	AMG 517
GTR19161078-01	AMG-517
GTR19218349-01	JNT-517
GTR19276925-01	CRBN ligand-517

Alternative Products

Catalog	Name
HY-12927-01	SX-517
JMA91342-01	SX 011
T70579-01	SX 3202
MBS3611903-01	SX-682
MBS5813693	SX-576
MBS5767679	SX-3228
574884	SX-011
MN 740784.50	Enhancer SX

SX-517

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