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GM 1489

CAT: 0013-GTR19190289-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19190289-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GM 1489 is a broad-spectrum matrix metalloproteinase (MMP) inhibitor effective against multiple MMP isoforms, including MMP-1, MMP-2, and MMP-9. It suppresses cancer cell invasion in vitro and demonstrates anti-inflammatory activity in vivo by inhibiting phorbol ester-induced skin inflammation and hyperplasia in mouse models.
CAS Number
171347-75-4
Field of Research
Protein Biochemistry
Smiles
C ([C@H] (NC ([C@H] (CC (C) C) CC (O) =O) =O) C (N[C@@H] (C) C1=CC=CC=C1) =O) C=2C=3C (NC2) =CC=CC3
Molecular Formula
C27H33N3O4
Molecular Weight
463.57
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

GM 1489

matrix metalloproteinase inhibitor; structure in first source

CAS Number171347-75-4
PubChem CID10322165
IUPAC Name(3R)-3-[[(2S)-3-(1H-indol-3-yl)-1-oxo-1-[[(1S)-1-phenylethyl]amino]propan-2-yl]carbamoyl]-5-methylhexanoic acid
Molecular FormulaC27H33N3O4
Molecular Weight463.6
XLogP3.3
Topological Polar Surface Area111
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count11
Heavy Atom Count34
Formal Charge0
Complexity691
SMILES
C[C@@H](C1=CC=CC=C1)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CC(C)C)CC(=O)O
InChI
InChI=1S/C27H33N3O4/c1-17(2)13-20(15-25(31)32)26(33)30-24(14-21-16-28-23-12-8-7-11-22(21)23)27(34)29-18(3)19-9-5-4-6-10-19/h4-12,16-18,20,24,28H,13-15H2,1-3H3,(H,29,34)(H,30,33)(H,31,32)/t18-,20+,24-/m0/s1
InChIKey
BLPWNGOQQLJQOL-NRYAXDJKSA-N
Chemical Structure
2D Structure
2D structure of GM 1489
CAS: 171347-75-4
CID: 10322165
Formula: C27H33N3O4
MW: 463.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight463.6
XLogP33.3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count11
Exact Mass463.24710654
Monoisotopic Mass463.24710654
Topological Polar Surface Area111 Ų
Heavy Atom Count34
Formal Charge0
Complexity691
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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