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FM19G11

CAT: 0804-HY-15672-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15672-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FM19G11 is a hypoxia-inducible factor-1-alpha (HIF-1α) inhibitor, and it inhibits hypoxia-induced luciferase activity with an IC50 of 80 nM in HeLa cells. FM19G11 modulates other signaling pathways, including mTOR and PI3K/Akt/eNOS, when the HIF-1α pathway is inactivated under normoxic conditions[1][2].
CAS Number
329932-55-0
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fm19g11.html
Purity
98.39
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OCC(C1=CC=C(C)C=C1)=O)C2=CC=CC(NC(C3=CC=C([N+]([O-])=O)C=C3[N+]([O-])=O)=O)=C2
Molecular Formula
C23H17N3O8
Molecular Weight
463.40
Precautions
H228, H315, H319
References & Citations
[1]Victoria MM, et, al. FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. J Biol Chem. 2010 Jan 8; 285 (2) : 1333-42.|[2]You CG, et, al. FM19G11 inhibits O 6 -methylguanine DNA-methyltransferase expression under both hypoxic and normoxic conditions. Cancer Med. 2018 May 15; 7 (7) : 3292-3300.|[3]Ana AA, et, al. FM19G11 and Ependymal Progenitor/Stem Cell Combinatory Treatment Enhances Neuronal Preservation and Oligodendrogenesis after Severe Spinal Cord Injury. Int J Mol Sci. 2018 Jan 9; 19 (1) : 200.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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