Products for Research Use Only
RegisterLogin

EW-7195

CAT: 0013-GTR19189727-02Size: 2 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19189727-02Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor (IC50 = 4.83 nM) that effectively blocks TGF-β1-induced Smad signaling and EMT. It has demonstrated activity in inhibiting breast cancer metastasis to the lung in research models, supporting its use in studying fibrosis and cancer biology.
CAS Number
1352609-28-9
Product Name Alternative
Smad, TGF-beta/Smad, TGFbeta/Smad, TGF-beta, TGFbeta, TGF-β/Smad, TGFβ, TGF-b/Smad, TGFb, ALK5, EW 7195, EW-7195, EW7195
Field of Research
Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.76% (May vary between batches)
Solubility
DMSO:40 mg/mL (98.42 mM)
Smiles
Cc1cccc (n1) -c1[nH]c (CNc2cccc (c2) C#N) nc1-c1ccc2ncnn2c1
Molecular Formula
C23H18N8
Molecular Weight
406.44
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

3-[[5-(6-methyl-2-pyridinyl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methylamino]benzonitrile
CAS Number1352609-28-9
PubChem CID54767248
IUPAC Name3-[[5-(6-methyl-2-pyridinyl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methylamino]benzonitrile
Molecular FormulaC23H18N8
Molecular Weight406.4
XLogP2.8
Topological Polar Surface Area108
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity649
SMILES
CC1=NC(=CC=C1)C2=C(N=C(N2)CNC3=CC=CC(=C3)C#N)C4=CN5C(=NC=N5)C=C4
InChI
InChI=1S/C23H18N8/c1-15-4-2-7-19(28-15)23-22(17-8-9-21-26-14-27-31(21)13-17)29-20(30-23)12-25-18-6-3-5-16(10-18)11-24/h2-10,13-14,25H,12H2,1H3,(H,29,30)
InChIKey
KEADGKSQIBFYEE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-[[5-(6-methyl-2-pyridinyl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methylamino]benzonitrile
CAS: 1352609-28-9
CID: 54767248
Formula: C23H18N8
MW: 406.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight406.4
XLogP32.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass406.16544261
Monoisotopic Mass406.16544261
Topological Polar Surface Area108 Ų
Heavy Atom Count31
Formal Charge0
Complexity649
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19163771-01EW-7197
GTR19030227A 71915
GTR19211099-01NU-7199
GTR19035182-01RP 71955
GTR19274513-01BI-7190
GTR19164284-01BYL-719
GTR19189357-01EPZ-719
GTR19153750-01ABT-719
GTR19268521-01APL-719
GTR19178130PF-719

Alternative Products

CatalogName
BA6517-5EW-7195
MBS131425EW-7197 (EW7197; EW 7197)
HY-P991252-01XmAb-7195
B1191-1EW-7197
449868EW 7197
PP45941-01H-EW-OH
HY-19161Bay-X-7195
bs-6908C-01EW-7197 Hydrochloride
A14213-200EW-7197 (Vactosertib) 200mg
A14213-10EW-7197 (Vactosertib) 10mg

Popular Products