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YNT-185

CAT: 0013-GTR19189857-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19189857-02Size:5 mg
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Description
YNT-185 is a potent and selective nonpeptide agonist for the orexin-2 receptor (OX2R), with an EC50 of 0.028 μM, showing over 98-fold selectivity over OX1R. It has demonstrated efficacy in alleviating narcolepsy-cataplexy symptoms in mouse models, making it a valuable tool for in vivo sleep/wake regulation research and in vitro OX2R signaling studies.
CAS Number
1804978-81-1
Product Name Alternative
OX2, OX Receptor, OXReceptor, YNT 185, YNT185, YNT-185
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.60% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:2.5 mg/mL (4.06 mM) ; DMSO:62 mg/mL (100.69 mM) ; H2O:Insoluble
Smiles
S (NC1=CC (NCCNC (=O) C2=C (N (C) C) C=CC=C2) =CC=C1) (=O) (=O) C3=C (OC) C=CC (=C3) C4=CC (C (N (C) C) =O) =CC=C4
Molecular Formula
C33H37N5O5S
Molecular Weight
615.74
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Ynt-185

an orexin type-2 receptor (OX2R) selective agonist

CAS Number1804978-81-1
PubChem CID122192250
IUPAC Name2-(dimethylamino)-N-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]benzamide
Molecular FormulaC33H37N5O5S
Molecular Weight615.7
XLogP4.6
Topological Polar Surface Area128
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count12
Heavy Atom Count44
Formal Charge0
Complexity1030
SMILES
CN(C)C1=CC=CC=C1C(=O)NCCNC2=CC(=CC=C2)NS(=O)(=O)C3=C(C=CC(=C3)C4=CC(=CC=C4)C(=O)N(C)C)OC
InChI
InChI=1S/C33H37N5O5S/c1-37(2)29-15-7-6-14-28(29)32(39)35-19-18-34-26-12-9-13-27(22-26)36-44(41,42)31-21-24(16-17-30(31)43-5)23-10-8-11-25(20-23)33(40)38(3)4/h6-17,20-22,34,36H,18-19H2,1-5H3,(H,35,39)
InChIKey
BXJSAMKIFDDLGI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ynt-185
CAS: 1804978-81-1
CID: 122192250
Formula: C33H37N5O5S
MW: 615.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight615.7
XLogP34.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count12
Exact Mass615.25154047
Monoisotopic Mass615.25154047
Topological Polar Surface Area128 Ų
Heavy Atom Count44
Formal Charge0
Complexity1030
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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