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Sebetralstat

CAT: 0013-GTR19189521-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19189521-04Size:10 mg
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Description
Sebetralstat (KVD900) is a potent and selective plasma kallikrein inhibitor used in metabolic disease research. It is a valuable tool for investigating kallikrein-mediated pathways in both in vitro biochemical assays and in vivo preclinical models of hereditary angioedema and related disorders.
CAS Number
1933514-13-6
Product Name Alternative
Plasma kallikrein (PKK), Sebetralstat, KVD 900, KVD900, KVD-900
Field of Research
Protein Biochemistry
Purity
97.24% (May vary between batches)
Solubility
DMSO:112.5 mg/mL (228.89 mM)
Smiles
COCc1nn (Cc2ccc (Cn3ccccc3=O) cc2) cc1C (=O) NCc1nccc (OC) c1F
Molecular Formula
C26H26FN5O4
Molecular Weight
491.51
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Sebetralstat

Hereditary angioedema (HAE) is a rare genetic disease that causes sudden, painful swelling episodes in various body locations that can be life-threatening, particularly when affecting the throat. Sebetralstat is the first and only oral on-demand treatment for HAE, providing a convenient alternative to injectable therapies that have been challenging for patients to use. This plasma kallikrein inhibitor works by reducing bradykinin, the substance that causes the characteristic swelling in HAE attacks. The U.S. Food and Drug Administration approved sebetralstat on July 7, 2025, for treating acute HAE attacks in patients aged 12 years and older.

CAS Number1933514-13-6
PubChem CID121365142
IUPAC NameN-[(3-fluoro-4-methoxy-2-pyridinyl)methyl]-3-(methoxymethyl)-1-[[4-[(2-oxo-1-pyridinyl)methyl]phenyl]methyl]pyrazole-4-carboxamide
Molecular FormulaC26H26FN5O4
Molecular Weight491.5
XLogP1.3
Topological Polar Surface Area98.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Heavy Atom Count36
Formal Charge0
Complexity803
SMILES
COCC1=NN(C=C1C(=O)NCC2=NC=CC(=C2F)OC)CC3=CC=C(C=C3)CN4C=CC=CC4=O
InChI
InChI=1S/C26H26FN5O4/c1-35-17-22-20(26(34)29-13-21-25(27)23(36-2)10-11-28-21)16-32(30-22)15-19-8-6-18(7-9-19)14-31-12-4-3-5-24(31)33/h3-12,16H,13-15,17H2,1-2H3,(H,29,34)
InChIKey
KGMPDQIYDKKXRD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Sebetralstat
CAS: 1933514-13-6
CID: 121365142
Formula: C26H26FN5O4
MW: 491.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight491.5
XLogP31.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count10
Exact Mass491.19688249
Monoisotopic Mass491.19688249
Topological Polar Surface Area98.6 Ų
Heavy Atom Count36
Formal Charge0
Complexity803
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C01631-5mgSebetralstat

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