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TH5427 hydrochloride

CAT: 0013-GTR19189273Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19189273Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TH5427 hydrochloride is a potent and selective NUDT5 inhibitor (IC50 = 29 nM) with 690-fold selectivity over MTH1. It blocks progestin-driven, PAR-dependent nuclear ATP production in breast cancer cells, inhibiting chromatin remodeling, gene expression, and cell proliferation in vitro. This makes it a valuable chemical probe for studying nucleotide metabolism in cancer research.
CAS Number
2253744-57-7
Field of Research
Cell Biology, Molecular Biology
Smiles
Cl.Cn1c2nc (N3CCNCC3) n (Cc3nnc (o3) -c3ccc (Cl) c (Cl) c3) c2c (=O) n (C) c1=O
Molecular Formula
C20H21Cl3N8O3
Molecular Weight
527.79
Storage Conditions
-20°C
Notes
For research use only.

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