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TH5427 hydrochloride

CAT: 0931-T39785Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T39785Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2253744-57-7
Target
Others, DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Others
Bioactivity
TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibits progestin-dependent, PAR-derived nuclear ATP synthesis in breast cancer cells, thereby impeding chromatin remodeling, gene regulation, and ultimately suppressing proliferation.
Smiles
Cl.Cn1c2nc(N3CCNCC3)n(Cc3nnc(o3)-c3ccc(Cl)c(Cl)c3)c2c(=O)n(C)c1=O
Molecular Formula
C20H21Cl3N8O3
Molecular Weight
527.79
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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