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DGTP

CAT: 0013-GTR19188616-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19188616-01Size:1 mg
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Description
DGTP (2'-Deoxyguanosine-5'-triphosphate) is a nucleotide building block highly prone to oxidation, forming products like 8-oxo-dGTP. This oxidative lesion is studied in vitro and in vivo for its role in mutagenesis, genome instability, and diseases such as cancer and neurodegeneration.
CAS Number
2564-35-4
Product Name Alternative
Analog, acid, 2'-Deoxyguanosine-5'-triphosphate, damage, deoxyribonucleic, DNASynthesis, dGTP, DNA Synthesis, DNA/RNA Synthesis, Inhibitor, guanosine, Nucleoside Antimetabolite, Nucleoside Antimetabolite/Analog, NucleosideAntimetabolite, nucleotide, inhibit, oxidative, synthesis, RNA Synthesis, RNASynthesis
Field of Research
Cell Biology, Molecular Biology
Purity
99.64% (May vary between batches)
Solubility
DMSO:Slightly soluble
Smiles
O=C1C2=C (N (C=N2) [C@@H]3O[C@H] (COP (OP (OP (=O) (O) O) (=O) O) (=O) O) [C@@H] (O) C3) NC (N) =N1
Molecular Formula
C10H16N5O13P3
Molecular Weight
507.18
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

dGTP

DGTP is a purine 2'-deoxyribonucleoside 5'-triphosphate having guanine as the nucleobase. It has a role as an Arabidopsis thaliana metabolite, a mouse metabolite, a Saccharomyces cerevisiae metabolite, a plant metabolite, an Escherichia coli metabolite and a human metabolite. It is a deoxyguanosine phosphate, a purine 2'-deoxyribonucleoside 5'-triphosphate and a guanyl deoxyribonucleotide. It is a conjugate acid of a dGTP(3-).

CAS Number2564-35-4
PubChem CID135398599
IUPAC Name[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular FormulaC10H16N5O13P3
Molecular Weight507.18
XLogP-5.6
Topological Polar Surface Area275
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count15
Rotatable Bond Count8
Heavy Atom Count31
Formal Charge0
Complexity895
SMILES
C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(NC3=O)N)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O
InChI
InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1
InChIKey
HAAZLUGHYHWQIW-KVQBGUIXSA-N
Chemical Structure
2D Structure
2D structure of dGTP
CAS: 2564-35-4
CID: 135398599
Formula: C10H16N5O13P3
MW: 507.18
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight507.18
XLogP3-5.6
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count15
Rotatable Bond Count8
Exact Mass506.99574658
Monoisotopic Mass506.99574658
Topological Polar Surface Area275 Ų
Heavy Atom Count31
Formal Charge0
Complexity895
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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