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UZH2

CAT: 0013-GTR19189057-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19189057-05Size:50 mg
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Description
UZH2 is a highly potent and selective small molecule inhibitor of METTL3, exhibiting an IC50 of 5 nM. It is a valuable research tool for investigating the role of m6A methylation in oncology, immunology, and developmental biology in both cellular and animal models.
CAS Number
2756566-45-5
Product Name Alternative
METTL3, UZH 2, UZH2, UZH-2
Purity
99.52% (May vary between batches)
Solubility
DMSO:< 5.14 mg/mL (10 mM)
Smiles
CNc1cc (ncn1) N1CCC2 (CC1) CN (CC (=O) N2) c1cc (F) c (CN2CCC (C) (C) CC2) cc1F
Molecular Formula
C27H37F2N7O
Molecular Weight
513.63
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Uzh2
CAS Number2756566-45-5
PubChem CID156587343
IUPAC Name4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one
Molecular FormulaC27H37F2N7O
Molecular Weight513.6
XLogP4
Topological Polar Surface Area76.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Heavy Atom Count37
Formal Charge0
Complexity783
SMILES
CC1(CCN(CC1)CC2=CC(=C(C=C2F)N3CC(=O)NC4(C3)CCN(CC4)C5=NC=NC(=C5)NC)F)C
InChI
InChI=1S/C27H37F2N7O/c1-26(2)4-8-34(9-5-26)15-19-12-21(29)22(13-20(19)28)36-16-25(37)33-27(17-36)6-10-35(11-7-27)24-14-23(30-3)31-18-32-24/h12-14,18H,4-11,15-17H2,1-3H3,(H,33,37)(H,30,31,32)
InChIKey
GYWOVBUGFWWSJR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Uzh2
CAS: 2756566-45-5
CID: 156587343
Formula: C27H37F2N7O
MW: 513.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight513.6
XLogP34
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass513.30276515
Monoisotopic Mass513.30276515
Topological Polar Surface Area76.6 Ų
Heavy Atom Count37
Formal Charge0
Complexity783
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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