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DDO-7263

CAT: 0013-GTR19187986-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19187986-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DDO-7263 is a 1,2,4-oxadiazole-based Nrf2 activator that binds to Rpn6, inhibiting 26S proteasome assembly and stabilizing ubiquitinated Nrf2. This activation of the Nrf2-ARE pathway confers anti-inflammatory activity, supporting its research use in models of oxidative stress and inflammation both in vitro and in vivo.
CAS Number
2254004-96-9
Product Name Alternative
Nrf2
Field of Research
Immunology & Inflammation, Metabolism Research
Purity
99.75% (May vary between batches)
Solubility
DMSO:16.1 mg/mL (58.92 mM) ;10% DMSO+90% Corn Oil:1.5 mg/mL (5.49 mM)
Smiles
Cc1ccc (cn1) -c1noc (n1) -c1ccc (F) c (F) c1
Molecular Formula
C14H9F2N3O
Molecular Weight
273.24
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole
CAS Number2254004-96-9
PubChem CID145989809
IUPAC Name5-(3,4-difluorophenyl)-3-(6-methyl-3-pyridinyl)-1,2,4-oxadiazole
Molecular FormulaC14H9F2N3O
Molecular Weight273.24
XLogP3
Topological Polar Surface Area51.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity334
SMILES
CC1=NC=C(C=C1)C2=NOC(=N2)C3=CC(=C(C=C3)F)F
InChI
InChI=1S/C14H9F2N3O/c1-8-2-3-10(7-17-8)13-18-14(20-19-13)9-4-5-11(15)12(16)6-9/h2-7H,1H3
InChIKey
HITVBBDLWZDVIV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole
CAS: 2254004-96-9
CID: 145989809
Formula: C14H9F2N3O
MW: 273.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight273.24
XLogP33
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass273.07136824
Monoisotopic Mass273.07136824
Topological Polar Surface Area51.8 Ų
Heavy Atom Count20
Formal Charge0
Complexity334
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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