Products for Research Use Only
RegisterLogin

ABBV-318

CAT: 0013-GTR19187179-01Size: 2 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19187179-01Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ABBV-318 is a dual small molecule inhibitor of the voltage-gated sodium channels hNav1.7 and hNav1.8, exhibiting IC50 values of 2.8 μM and 3.8 μM, respectively. It serves as a research tool for investigating pain mechanisms and related disorders in both in vitro and in vivo experimental models.
CAS Number
1802848-94-7
Product Name Alternative
Sodium Channel, SodiumChannel, Nav1.7 channel, Nav1.8 channel
Field of Research
Pharmacology & Drug Discovery
Purity
99.61% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.87 mM) ; DMSO:150 mg/mL (370.05 mM)
Smiles
F[C@@H]1CCN (C1) C (=O) c1ccc2cc (Oc3ccc (cn3) C (F) (F) F) ccc2n1
Molecular Formula
C20H15F4N3O2
Molecular Weight
405.35
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Abbv-318
CAS Number1802848-94-7
PubChem CID118273623
IUPAC Name[(3R)-3-fluoropyrrolidin-1-yl]-[6-[[5-(trifluoromethyl)-2-pyridinyl]oxy]quinolin-2-yl]methanone
Molecular FormulaC20H15F4N3O2
Molecular Weight405.3
XLogP4.2
Topological Polar Surface Area55.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Heavy Atom Count29
Formal Charge0
Complexity591
SMILES
C1CN(C[C@@H]1F)C(=O)C2=NC3=C(C=C2)C=C(C=C3)OC4=NC=C(C=C4)C(F)(F)F
InChI
InChI=1S/C20H15F4N3O2/c21-14-7-8-27(11-14)19(28)17-4-1-12-9-15(3-5-16(12)26-17)29-18-6-2-13(10-25-18)20(22,23)24/h1-6,9-10,14H,7-8,11H2/t14-/m1/s1
InChIKey
FWLFRXVPNVBXGR-CQSZACIVSA-N
Chemical Structure
2D Structure
2D structure of Abbv-318
CAS: 1802848-94-7
CID: 118273623
Formula: C20H15F4N3O2
MW: 405.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight405.3
XLogP34.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass405.11003938
Monoisotopic Mass405.11003938
Topological Polar Surface Area55.3 Ų
Heavy Atom Count29
Formal Charge0
Complexity591
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19175760-01SR-318
GTR19166676-01BOS-318
GTR19276943-01CRBN ligand-318
GTR19217488-01ABBV-467
GTR19237793-01ABBV-992
GTR19062959-01HIV gp120 (318-327)
GTR19195983ABBV-221
GTR19189728ABBV-167
GTR19170421-01ABBV-744
GTR19162771-01ABBV-744

Alternative Products

CatalogName
T62000-01ABBV-318
HY-142209-01ABBV-167
T4697-01ABBV-744
T83219-01ABBV-467
MBS3844614-01ABBV-4083
MBS131345Mivebresib (ABBV075, ABBV-075, ABBV 075)
BA166477-01ABBV 744
T89551-01ABBV-992

Popular Products