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SR-318

CAT: 0013-GTR19175760-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19175760-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SR-318 is a potent and selective p38 MAPK inhibitor, with IC50 values of 5 nM and 32 nM for p38α and p38β, respectively. It effectively suppresses TNF-α release in whole blood (IC50 = 283 nM), making it a valuable tool for investigating inflammatory pathways in cellular and animal models of disease.
CAS Number
2413286-32-3
Product Name Alternative
SR 318, SR318, SR-318, TNF-α, TNFR, TNF Receptor, whole, p38 MAPK, p38MAPK, p38α, p38α/β, p38β, Tumor Necrosis Factor Receptor, anti-inflammatory, anti-cancer, blood, Inhibitor, inhibit
Field of Research
Cell Biology, Signal Transduction
Purity
99.53% (May vary between batches)
Solubility
DMSO:125 mg/mL (271.99 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.7 mM)
Smiles
Nc1c (cnn1-c1ccccc1) C (=O) NCc1ccc (cc1) C (=O) NCCCC1CCCCC1
Molecular Formula
C27H33N5O2
Molecular Weight
459.58
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

SR-318

p38 MAP kinase inhibitor

CAS Number2413286-32-3
PubChem CID139030333
IUPAC Name5-amino-N-[[4-(3-cyclohexylpropylcarbamoyl)phenyl]methyl]-1-phenylpyrazole-4-carboxamide
Molecular FormulaC27H33N5O2
Molecular Weight459.6
XLogP5.6
Topological Polar Surface Area102
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count9
Heavy Atom Count34
Formal Charge0
Complexity639
SMILES
C1CCC(CC1)CCCNC(=O)C2=CC=C(C=C2)CNC(=O)C3=C(N(N=C3)C4=CC=CC=C4)N
InChI
InChI=1S/C27H33N5O2/c28-25-24(19-31-32(25)23-11-5-2-6-12-23)27(34)30-18-21-13-15-22(16-14-21)26(33)29-17-7-10-20-8-3-1-4-9-20/h2,5-6,11-16,19-20H,1,3-4,7-10,17-18,28H2,(H,29,33)(H,30,34)
InChIKey
HXNUFFCHRIWTRZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of SR-318
CAS: 2413286-32-3
CID: 139030333
Formula: C27H33N5O2
MW: 459.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight459.6
XLogP35.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count9
Exact Mass459.26342531
Monoisotopic Mass459.26342531
Topological Polar Surface Area102 Ų
Heavy Atom Count34
Formal Charge0
Complexity639
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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