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JNc-440

CAT: 0013-GTR19186058-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19186058-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNc-440 is a research compound that acts as a potent anti-hypertensive agent by promoting the TRPV4-KCa2.3 channel interaction in endothelial cells, leading to enhanced vasodilation. This mechanism has been demonstrated to produce hypotensive effects in murine in vivo models, supporting its use in cardiovascular and vascular biology research.
CAS Number
1119503-63-7
Field of Research
Pharmacology & Drug Discovery
Purity
99.58% (May vary between batches)
Smiles
O=C1N=C (NC=2C=CC=CC12) C (=O) NCCCNC (=O) C (C=3C=CC=CC3) C=4C=CC=CC4
Molecular Formula
C26H24N4O3
Molecular Weight
440.49
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(3-(2,2-diphenylacetamido)propyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide
CAS Number1119503-63-7
PubChem CID135658581
IUPAC NameN-[3-[(2,2-diphenylacetyl)amino]propyl]-4-oxo-3H-quinazoline-2-carboxamide
Molecular FormulaC26H24N4O3
Molecular Weight440.5
XLogP3.4
Topological Polar Surface Area99.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Heavy Atom Count33
Formal Charge0
Complexity707
SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NCCCNC(=O)C3=NC4=CC=CC=C4C(=O)N3
InChI
InChI=1S/C26H24N4O3/c31-24-20-14-7-8-15-21(20)29-23(30-24)26(33)28-17-9-16-27-25(32)22(18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-8,10-15,22H,9,16-17H2,(H,27,32)(H,28,33)(H,29,30,31)
InChIKey
VMRVWMQQRPXUQU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(3-(2,2-diphenylacetamido)propyl)-4-oxo-3,4-dihydroquinazoline-2-carboxamide
CAS: 1119503-63-7
CID: 135658581
Formula: C26H24N4O3
MW: 440.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight440.5
XLogP33.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Exact Mass440.18484064
Monoisotopic Mass440.18484064
Topological Polar Surface Area99.7 Ų
Heavy Atom Count33
Formal Charge0
Complexity707
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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