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ULK1-IN-2

CAT: 0013-GTR19185316-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19185316-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ULK1-IN-2 is a potent and selective ULK1 inhibitor that induces apoptosis and blocks autophagy, demonstrating high cytotoxicity (IC50 = 1.94 μM in A549 cells) . It is a valuable chemical probe for studying autophagy-dependent processes in non-small cell lung cancer research, both in vitro and in vivo.
CAS Number
2497409-01-3
Product Name Alternative
Apoptosis, ULK1
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction
Purity
99.07% (May vary between batches)
Solubility
DMSO:45 mg/mL (90.86 mM)
Smiles
O (C) C1=C (OC) C=C (NC=2N=C (OC3=C (F) C=C (N (=O) =O) C=C3) C (Br) =CN2) C=C1OC
Molecular Formula
C19H16BrFN4O6
Molecular Weight
495.26
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Ulk1-IN-2
CAS Number2497409-01-3
PubChem CID162658365
IUPAC Name5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl)pyrimidin-2-amine
Molecular FormulaC19H16BrFN4O6
Molecular Weight495.3
XLogP4.5
Topological Polar Surface Area121
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Heavy Atom Count31
Formal Charge0
Complexity576
SMILES
COC1=CC(=CC(=C1OC)OC)NC2=NC=C(C(=N2)OC3=C(C=C(C=C3)[N+](=O)[O-])F)Br
InChI
InChI=1S/C19H16BrFN4O6/c1-28-15-6-10(7-16(29-2)17(15)30-3)23-19-22-9-12(20)18(24-19)31-14-5-4-11(25(26)27)8-13(14)21/h4-9H,1-3H3,(H,22,23,24)
InChIKey
CVOMZGNACQPPDA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ulk1-IN-2
CAS: 2497409-01-3
CID: 162658365
Formula: C19H16BrFN4O6
MW: 495.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight495.3
XLogP34.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass494.02372
Monoisotopic Mass494.02372
Topological Polar Surface Area121 Ų
Heavy Atom Count31
Formal Charge0
Complexity576
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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