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Imlunestrant

CAT: 0013-GTR19184956-03Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19184956-03Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Imlunestrant
CAS Number
2408840-26-4
Product Name Alternative
LY3484356, LY-3484356
Field of Research
Metabolism Research
Purity
97.35% (May vary between batches)
Solubility
DMSO:140 mg/mL (266.92 mM)
Smiles
OC1=CC=2C (=C3C (C=4C (O[C@@H]3C5=CC=C (OCCN6CC (CF) C6) C=C5) =CC (C (F) (F) F) =CC4) =CN2) C=C1
Molecular Formula
C29H24F4N2O3
Molecular Weight
524.51
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Imlunestrant

Imlunestrant is a brain-penetrant selective estrogen receptor antagonist and degrader. The FDA approved imlunestrant on September 25, 2025 as a treatment for estrogen receptor (ER)-positive, HER2-negative, estrogen receptor 1 (ESR1)-mutated advanced or metastatic breast cancer with progression on at least one line of endocrine therapy. Imlunestrant works by antagonizing ER transcriptional activity and, by forming an unstable drug-receptor complex, promotes ER degradation via the ubiquitin-proteasome pathway. In clinical trials, imlunestrant has been investigated as monotherapy and in combination with other drugs in breast cancer patients.

CAS Number2408840-26-4
PubChem CID146603228
IUPAC Name(5R)-5-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-8-(trifluoromethyl)-5H-chromeno[4,3-c]quinolin-2-ol
Molecular FormulaC29H24F4N2O3
Molecular Weight524.5
XLogP6
Topological Polar Surface Area54.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count38
Formal Charge0
Complexity788
SMILES
C1C(CN1CCOC2=CC=C(C=C2)[C@@H]3C4=C5C=CC(=CC5=NC=C4C6=C(O3)C=C(C=C6)C(F)(F)F)O)CF
InChI
InChI=1S/C29H24F4N2O3/c30-13-17-15-35(16-17)9-10-37-21-5-1-18(2-6-21)28-27-23-8-4-20(36)12-25(23)34-14-24(27)22-7-3-19(29(31,32)33)11-26(22)38-28/h1-8,11-12,14,17,28,36H,9-10,13,15-16H2/t28-/m1/s1
InChIKey
UVBQMXOKKDCBJN-MUUNZHRXSA-N
Chemical Structure
2D Structure
2D structure of Imlunestrant
CAS: 2408840-26-4
CID: 146603228
Formula: C29H24F4N2O3
MW: 524.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight524.5
XLogP36
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass524.17230528
Monoisotopic Mass524.17230528
Topological Polar Surface Area54.8 Ų
Heavy Atom Count38
Formal Charge0
Complexity788
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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