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DI-1859

CAT: 0013-GTR19184681-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19184681-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DI-1859 is a potent, selective, and covalent DCN1 inhibitor that blocks cullin-3 neddylation. This action stabilizes the NRF2 protein in cellular and in vivo models, as demonstrated by its efficacy in protecting against acetaminophen-induced hepatotoxicity in mice, highlighting its utility in studying CRL3 and oxidative stress pathways.
CAS Number
2247061-09-0
Field of Research
Protein Biochemistry
Smiles
CCC (=O) N[C@@H] (Cc1nc2ccc (cc2s1) C (C) C) C (=O) N[C@H] (CNC (=O) C (=C) CN (C) C) C1CCCCC1
Molecular Formula
C30H45N5O3S
Molecular Weight
555.78
Storage Conditions
-20°C
Notes
For research use only.

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