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SB-408124

CAT: 0013-GTR19184309-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19184309-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB408124 is a potent and selective small molecule antagonist of the orexin-1 (OX1) receptor, exhibiting Ki values of 57 nM and 27 nM in whole cell and membrane assays, respectively, with 50-fold selectivity over the OX2 receptor. This compound is a valuable research tool for investigating orexin system function in sleep, addiction, and stress-related behaviors in both in vitro and in vivo models.
CAS Number
288150-92-5
Product Name Alternative
Selectivity, water, SB 408124, SB408124, SB-408124, intake, HCRT Receptor, Inhibitor, Hypocretin Receptor, membrane, Orexin Receptor (OX Receptor), OXReceptor, OX Receptor, OX1 (membrane), OX1 (whole cell), inhibit, cell
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.14% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:2.5 mg/mL (7.02 mM) ; DMSO:62.5 mg/mL (175.38 mM)
Smiles
CN (C) c1ccc (NC (=O) Nc2cc (C) nc3c (F) cc (F) cc23) cc1
Molecular Formula
C19H18F2N4O
Molecular Weight
356.37
Storage Conditions
-20°C
Notes
For research use only.

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