Products for Research Use Only
RegisterLogin

Voreloxin

CAT: 0013-GTR19184299-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19184299-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Voreloxin (SNS-595) is a topoisomerase II-targeting anticancer agent with broad-spectrum activity. It has demonstrated efficacy in preclinical in vitro and in vivo models against various cancers, including acute myeloid leukemia and solid tumors, supporting its research use in oncology and pharmacology studies.
CAS Number
175414-77-4
Field of Research
Cell Biology, Molecular Biology
Smiles
CN[C@H]1CN (C[C@@H]1OC) C2=NC3=C (C=C2) C (=O) C (=CN3C4=NC=CS4) C (=O) O
Molecular Formula
C18H19N5O4S
Molecular Weight
401.44
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Vosaroxin

Vosaroxin is a 1,8-naphthyridine derivative that is 1,8-naphthyridin-4(1H)-one substituted by 1,3-thiazol-2-yl, carboxy, and (3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl groups at positions 1, 3, and 7, respectively. It targets topoisomerase II and induces site-selective double-strand breaks in DNA, leading to apoptosis in cancer cells. It has a role as a radiosensitizing agent, a topoisomerase II inhibitor, an intercalator, an antineoplastic agent and an apoptosis inducer. It is a quinolone, a monocarboxylic acid, an ether, a member of pyrrolidines, a member of 1,3-thiazoles, a cyclic ketone, a secondary amino compound and a 1,8-naphthyridine derivative.

CAS Number175414-77-4
PubChem CID9952884
IUPAC Name7-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,8-naphthyridine-3-carboxylic acid
Molecular FormulaC18H19N5O4S
Molecular Weight401.4
XLogP-0.3
Topological Polar Surface Area136
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count5
Heavy Atom Count28
Formal Charge0
Complexity662
SMILES
CN[C@H]1CN(C[C@@H]1OC)C2=NC3=C(C=C2)C(=O)C(=CN3C4=NC=CS4)C(=O)O
InChI
InChI=1S/C18H19N5O4S/c1-19-12-8-22(9-13(12)27-2)14-4-3-10-15(24)11(17(25)26)7-23(16(10)21-14)18-20-5-6-28-18/h3-7,12-13,19H,8-9H2,1-2H3,(H,25,26)/t12-,13-/m0/s1
InChIKey
XZAFZXJXZHRNAQ-STQMWFEESA-N
Chemical Structure
2D Structure
2D structure of Vosaroxin
CAS: 175414-77-4
CID: 9952884
Formula: C18H19N5O4S
MW: 401.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight401.4
XLogP3-0.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count5
Exact Mass401.11577528
Monoisotopic Mass401.11577528
Topological Polar Surface Area136 Ų
Heavy Atom Count28
Formal Charge0
Complexity662
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
202650Voreloxin
A3925-5Voreloxin Hydrochloride
A14158-10Voreloxin 10mg
HY-16518-01Voreloxin (Hydrochloride)
A14158-50Voreloxin 50mg
A14158-1Voreloxin 1mg
A14158-25Voreloxin 25mg
A14158-5Voreloxin 5mg
A15280-10Voreloxin Hydrochloride 10mg
A15280-50Voreloxin Hydrochloride 50mg

Popular Products