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AT-533

CAT: 0013-GTR19184245-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19184245-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AT-533 is a dual Hsp90 and HSV inhibitor that suppresses tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling axis and downstream pathways like Erk1/2 and Akt/mTOR. It has demonstrated anti-angiogenic activity in vitro by inhibiting HUVEC migration, invasion, and tube formation, supporting its research application in oncology and virology studies.
CAS Number
908112-37-8
Product Name Alternative
AT533, AT-533, AT 533, Benzamide,2[ (trans4hydroxycyclohexyl) amino]4 (4,5,6,7tetrahydro3,6,6trimethyl4oxo1Hindazol1yl), HSV, HSP90
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Infectious Disease & Virology, Metabolism Research, Signal Transduction
Purity
99.54% (May vary between batches)
Solubility
DMSO:60 mg/mL (146.16 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.87 mM)
Smiles
Cc1nn (c2CC (C) (C) CC (=O) c12) -c1ccc (C (N) =O) c (N[C@H]2CC[C@H] (O) CC2) c1
Molecular Formula
C23H30N4O3
Molecular Weight
410.51
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-[(4-Hydroxycyclohexyl)amino]-4-(3,6,6-trimethyl-4-oxo-5,7-dihydroindazol-1-yl)benzamide
CAS Number908112-37-8
PubChem CID24820800
IUPAC Name2-[(4-hydroxycyclohexyl)amino]-4-(3,6,6-trimethyl-4-oxo-5,7-dihydroindazol-1-yl)benzamide
Molecular FormulaC23H30N4O3
Molecular Weight410.5
XLogP3.3
Topological Polar Surface Area110
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count30
Formal Charge0
Complexity661
SMILES
CC1=NN(C2=C1C(=O)CC(C2)(C)C)C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O
InChI
InChI=1S/C23H30N4O3/c1-13-21-19(11-23(2,3)12-20(21)29)27(26-13)15-6-9-17(22(24)30)18(10-15)25-14-4-7-16(28)8-5-14/h6,9-10,14,16,25,28H,4-5,7-8,11-12H2,1-3H3,(H2,24,30)
InChIKey
FMOSGTTYAFQMSD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-[(4-Hydroxycyclohexyl)amino]-4-(3,6,6-trimethyl-4-oxo-5,7-dihydroindazol-1-yl)benzamide
CAS: 908112-37-8
CID: 24820800
Formula: C23H30N4O3
MW: 410.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight410.5
XLogP33.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass410.23179083
Monoisotopic Mass410.23179083
Topological Polar Surface Area110 Ų
Heavy Atom Count30
Formal Charge0
Complexity661
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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