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ALE-0540

CAT: 0013-GTR19183598-07Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19183598-07Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALE-0540 is a small molecule inhibitor that selectively blocks NGF binding to both its p75 and TrkA receptors, thereby disrupting downstream TrkA-mediated signaling and biological activity. This tool compound is used in vitro and in vivo to investigate neurotrophin pathways in pain, neurodegeneration, and cancer research.
CAS Number
234779-34-1
Product Name Alternative
Trk receptor, TrkA, Trkreceptor, ALE 0540, ALE0540, ALE-0540
Field of Research
Signal Transduction
Purity
97.25% (May vary between batches)
Solubility
DMSO:50 mg/mL (165.98 mM)
Smiles
O=C1C=2C=3C (C (=O) N1NCCO) =CC=CC3C=C (N (=O) =O) C2
Molecular Formula
C14H11N3O5
Molecular Weight
301.25
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Ale-0540

structure in first source

CAS Number234779-34-1
PubChem CID2826530
IUPAC Name2-(2-hydroxyethylamino)-5-nitrobenzo[de]isoquinoline-1,3-dione
Molecular FormulaC14H11N3O5
Molecular Weight301.25
XLogP1.1
Topological Polar Surface Area115
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity491
SMILES
C1=CC2=CC(=CC3=C2C(=C1)C(=O)N(C3=O)NCCO)[N+](=O)[O-]
InChI
InChI=1S/C14H11N3O5/c18-5-4-15-16-13(19)10-3-1-2-8-6-9(17(21)22)7-11(12(8)10)14(16)20/h1-3,6-7,15,18H,4-5H2
InChIKey
SURCGQGDUADKBL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ale-0540
CAS: 234779-34-1
CID: 2826530
Formula: C14H11N3O5
MW: 301.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight301.25
XLogP31.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass301.06987046
Monoisotopic Mass301.06987046
Topological Polar Surface Area115 Ų
Heavy Atom Count22
Formal Charge0
Complexity491
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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573648ALE-0540
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VP 581B-4ALSLAS DECK ADAPTOR, Anodized Aluminum, for use with Pressure Reaction Blocks VP 416-ALE-48-HP, VP 416-ALE-96-HP, and with VP 416-ALE-MP when heating is required. Only one unit is required for the high-pressure reactors but two units are required for the VP 416-ALE-MP
MBS1085790-01Recombinant Leishmania braziliensis Ecotin-like protein 2 (LbrM15_V2.0540, LbrM_15_0540)
MBS1147427-01Recombinant Leishmania infantum Ecotin-like protein 3 (LinJ15.0540, LinJ_15_0540)
VP 416-96-MAT-HPASSEMBLY MAT, for VP 416-ALE-96-HP Pressure Reaction Block, 115.3mm x 78mm

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