Primidone

CAT: 0804-HY-B0339-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

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CAT#:0804-HY-B0339-02Size:10 mM - 1 mL

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Description

Primidone is the orally active inhibitor for TRPM3 (IC50 = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent[1][2][3].

CAS Number

125-33-7

UNSPSC

12352005

Hazard Statement

H302, H351

Target

GABA Receptor; Necroptosis; RIP kinase; Sodium Channel; TRP Channel

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/primidone.html

Purity

99.96

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C(C1(CC)C2=CC=CC=C2)NCNC1=O

Molecular Formula

C12H14N2O2

Molecular Weight

218.25

Precautions

H302, H351

References & Citations

[1]Krügel U, et al., Primidone inhibits TRPM3 and attenuates thermal nociception in vivo. Pain. 2017 May;158 (5) :856-867.|[2]Riebeling T, et al., Primidone blocks RIPK1-driven cell death and inflammation. Cell Death Differ. 2021 May;28 (5) :1610-1626.|[3]Vogelnik Žakelj K, et al., Mechanisms of tremor-modulating effects of primidone and propranolol in essential tremor. Parkinsonism Relat Disord. 2024 Nov;128:107151.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Chemical Information

Primidone

Primidone can cause cancer according to The National Toxicology Program.

CAS Number	125-33-7
PubChem CID	4909
IUPAC Name	5-ethyl-5-phenyl-1,3-diazinane-4,6-dione
Molecular Formula	C12H14N2O2
Molecular Weight	218.25
XLogP	0.9
Topological Polar Surface Area	58.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Heavy Atom Count	16
Formal Charge	0
Complexity	279

SMILES

CCC1(C(=O)NCNC1=O)C2=CC=CC=C2

InChI

InChI=1S/C12H14N2O2/c1-2-12(9-6-4-3-5-7-9)10(15)13-8-14-11(12)16/h3-7H,2,8H2,1H3,(H,13,15)(H,14,16)

InChIKey

DQMZLTXERSFNPB-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 125-33-7

CID: 4909

Formula: C12H14N2O2

MW: 218.25

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	218.25
XLogP3	0.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Exact Mass	218.105527694
Monoisotopic Mass	218.105527694
Topological Polar Surface Area	58.2 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	279
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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RM-P183200-01	Primidone

Primidone

Chemical Information

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