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WRG-28

CAT: 0013-GTR19177850-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19177850-05Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WRG-28 is a potent and selective allosteric inhibitor of Discoidin Domain Receptor 2 (DDR2), exhibiting an IC50 of 230 nM. It is a valuable chemical probe for investigating DDR2's role in fibrosis and oncology research, enabling both in vitro biochemical assays and in vivo disease model studies.
CAS Number
1913291-02-7
Product Name Alternative
Rheumatoid arthritis, WRG 28, WRG28, WRG-28, breast cancer, DiscoidinDomainReceptor, Discoidin Domain Receptor, Discoidin Domain Receptor (DDR), DiscoidinDomainReceptor (DDR), 4T1 breast cancer cells, BT549, CAFs, joint destruction, inhibit, Inhibitor, HEK293, DDR2, DDR
Field of Research
Signal Transduction
Purity
97.21% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.44 mM) ; DMSO:15 mg/mL (36.55 mM)
Smiles
CCNS (=O) (=O) c1ccc (COc2ccc3nc4ccc (=O) cc4oc3c2) cc1
Molecular Formula
C21H18N2O5S
Molecular Weight
410.44
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-Ethyl-4-(((3-oxo-3H-phenoxazin-7-yl)oxy)methyl)benzenesulfonamide
CAS Number1913291-02-7
PubChem CID139035038
IUPAC NameN-ethyl-4-[(7-oxophenoxazin-3-yl)oxymethyl]benzenesulfonamide
Molecular FormulaC21H18N2O5S
Molecular Weight410.4
XLogP2.3
Topological Polar Surface Area102
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count29
Formal Charge0
Complexity818
SMILES
CCNS(=O)(=O)C1=CC=C(C=C1)COC2=CC3=C(C=C2)N=C4C=CC(=O)C=C4O3
InChI
InChI=1S/C21H18N2O5S/c1-2-22-29(25,26)17-7-3-14(4-8-17)13-27-16-6-10-19-21(12-16)28-20-11-15(24)5-9-18(20)23-19/h3-12,22H,2,13H2,1H3
InChIKey
AARVTLIQNGAELZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-Ethyl-4-(((3-oxo-3H-phenoxazin-7-yl)oxy)methyl)benzenesulfonamide
CAS: 1913291-02-7
CID: 139035038
Formula: C21H18N2O5S
MW: 410.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight410.4
XLogP32.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass410.09364285
Monoisotopic Mass410.09364285
Topological Polar Surface Area102 Ų
Heavy Atom Count29
Formal Charge0
Complexity818
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA8897-50WRG-28
A18832-10WRG-28 10mg
HY-114169SWRG-28-d5
A18832-100WRG-28 100mg
A18832-50WRG-28 50mg
A18832-25WRG-28 25mg
A18832-5WRG-28 5mg
A18832-1WRG-28 1mg
A18832-10mM-DWRG-28 10mM * 1mL in DMSO
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