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Anamorelin

CAT: 0013-GTR19177601-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19177601-01Size:5 mg
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Description
Anamorelin (ONO-7643) is a potent and selective ghrelin receptor agonist, demonstrating an EC50 of 0.74 nM in FLIPR-based assays. It is utilized in research on cancer cachexia, appetite stimulation, and muscle wasting, with applications in both in vitro mechanistic studies and in vivo animal models.
CAS Number
249921-19-5
Product Name Alternative
Anamorelin, inhibit, ONO 7643, ONO7643, ONO-7643, Inhibitor, Growth hormone secretagogue receptor, GHSR, GHS-R, ghrelin receptor, RC1291, RC-1291, RC 1291
Field of Research
Pharmacology & Drug Discovery
Purity
99.35% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.66 mM) ; DMSO:250 mg/mL (457.29 mM)
Smiles
CN (C) N (C) C (=O) [C@@]1 (Cc2ccccc2) CCCN (C1) C (=O) [C@@H] (Cc1c[nH]c2ccccc12) NC (=O) C (C) (C) N
Molecular Formula
C31H42N6O3
Molecular Weight
546.7
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Anamorelin

Anamorelin is a synthetic, orally bioavailable, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of ghrelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play a direct role in cancer-related loss of appetite.

CAS Number249921-19-5
PubChem CID9828911
IUPAC Name2-amino-N-[(2R)-1-[(3R)-3-benzyl-3-[dimethylamino(methyl)carbamoyl]piperidin-1-yl]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide
Molecular FormulaC31H42N6O3
Molecular Weight546.7
XLogP2.8
Topological Polar Surface Area115
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Heavy Atom Count40
Formal Charge0
Complexity904
SMILES
CC(C)(C(=O)N[C@H](CC1=CNC2=CC=CC=C21)C(=O)N3CCC[C@](C3)(CC4=CC=CC=C4)C(=O)N(C)N(C)C)N
InChI
InChI=1S/C31H42N6O3/c1-30(2,32)28(39)34-26(18-23-20-33-25-15-10-9-14-24(23)25)27(38)37-17-11-16-31(21-37,29(40)36(5)35(3)4)19-22-12-7-6-8-13-22/h6-10,12-15,20,26,33H,11,16-19,21,32H2,1-5H3,(H,34,39)/t26-,31-/m1/s1
InChIKey
VQPFSIRUEPQQPP-MXBOTTGLSA-N
Chemical Structure
2D Structure
2D structure of Anamorelin
CAS: 249921-19-5
CID: 9828911
Formula: C31H42N6O3
MW: 546.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight546.7
XLogP32.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Exact Mass546.33183922
Monoisotopic Mass546.33183922
Topological Polar Surface Area115 Ų
Heavy Atom Count40
Formal Charge0
Complexity904
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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