Cilnidipine

CAT: 0013-GTR19177117-02Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19177117-02Size:50 mg

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Description

Cilnidipine (FRC-8653) is a dual L/N-type calcium channel blocker with antihypertensive properties. Its sympatholytic and neuroprotective effects are utilized in cardiovascular and neurological research, including studies on hypertension and stroke models in vivo and in cellular assays in vitro.

CAS Number

132203-70-4

Product Name Alternative

Antihypertensive, Ca channels, Ca2+ channels, Calcium Channel, CalciumChannel, Cilnidipine, channel, dihydropyridine Ca, Dual L-and N-type calcium channel, long-acting, inhibit, FRC 8653, FRC8653, FRC-8653, Inhibitor

Field of Research

Metabolism Research, Pharmacology & Drug Discovery

Purity

98.85% (May vary between batches)

Solubility

DMSO:262.5 mg/mL (532.97 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.06 mM) ; Ethanol:4.9 mg/mL (9.95 mM)

Smiles

COCCOC (=O) C1=C (C) NC (C) =C (C1C1=CC=CC (=C1) [N+] ([O-]) =O) C (=O) OC\C=C\C1=CC=CC=C1

Molecular Formula

C27H28N2O7

Molecular Weight

492.52

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Cilnidipine

Cilnidipine is a diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive. It has a role as a cardiovascular drug, an antihypertensive agent and a calcium channel blocker. It is a 2-methoxyethyl ester, a C-nitro compound and a dihydropyridine.

CAS Number	132203-70-4
PubChem CID	5282138
IUPAC Name	3-O-(2-methoxyethyl) 5-O-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Molecular Formula	C27H28N2O7
Molecular Weight	492.5
XLogP	4.4
Topological Polar Surface Area	120
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	11
Heavy Atom Count	36
Formal Charge	0
Complexity	896

SMILES

CC1=C(C(C(=C(N1)C)C(=O)OC/C=C/C2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCOC

InChI

InChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+

InChIKey

KJEBULYHNRNJTE-DHZHZOJOSA-N

Chemical Structure

2D Structure

CAS: 132203-70-4

CID: 5282138

Formula: C27H28N2O7

MW: 492.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	492.5
XLogP3	4.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	11
Exact Mass	492.18965124
Monoisotopic Mass	492.18965124
Topological Polar Surface Area	120 Å²
Heavy Atom Count	36
Formal Charge	0
Complexity	896
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
A1447-5.1	Cilnidipine

Cilnidipine

Chemical Information

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